TOPFITTailored Oligomers and Polymers for Information Technology
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The area under the busulfan concentration-time curve (AUC) was calculated using TOPFIT by noncompartmental analysis (14).
The area under the concentration-time curve up to time t ([AUC.sup.0-t]), expressed as mmol x [L.sup.-1] x min, was calculated by the trapezoidal rule, using the pharmacokinetic computer program Topfit 2.0 (11).