TRACPTartrate Resistant Acid Phosphatase (marker of bone resorption)
Copyright 1988-2018, All rights reserved.
References in periodicals archive ?
The expressions of four osteoclast-specific expression genes, including TRACP, MMP-2, MMP-9, and c-Src, were analyzed by using RT-PCR, in which GAPDH was employed as a control for both cDNA quality and efficiency of the PCR amplification.
Tartrate-resistant acid phosphatase (TRACP 5b): a biomarker of bone resorption rate in support of drug development: modification, validation and application of the BoneTRAP kit assay.
The serum levels of calcium, phosphorus, alkaline phosphatase (ALP), magnesium, thyroid-stimulating hormone (TSH), free thyroxine (f[T.sub.4]), parathyroid hormone (PTH), 25 hydroxycholecalciferol [25(OH)[D.sub.3]-Vitamin D], PINP, TRACP 5b, and urine calcium/creatinine ratio were analyzed in the biochemistry laboratory of Baskent University.
TRACP staining further confirmed that the numbers of TRACP+ multinucleated osteoclasts were significantly increased by the treatment of siRNAs specifically targeting EphB4 in an inflammatory microenvironment.
In this study of a cohort of postmenopausal women, we evaluated the effect of iron overload on baseline characteristics (including age, years of menopause, Ca, P, BMI, liver and kidney function, glucose metabolism, lipid metabolism, and inflammatory response), BMD, TRACP, ALP, and type I collagen degradation products.
In the malleolar fracture group, no changes were observed in bone ALP, PICP, TRACP 5b, or PIIINP concentrations between presentation at the emergency room and time of osteosynthesis, whereas OC and ICTP increased and YKL-40 decreased significantly (P <0.05).
"In the markets where bone TRACP 5b has been professionally marketed such as the USA and Germany, it has seen a rapid and sustained growth in uptake by researchers and clinical triallists.
Tartrate-resistant acid phosphatase (TRACP), an iron-containing 35-kDa enzyme, is produced in osteoclasts, beginning early in their development.
Individuals with ADO2 have significantly increased serum activities of total tartrate-resistant acid phosphatase (TRACP; EC and the BB isoenzyme of creatine kinase (CK-BB) (17-19).
Bone-resorbing osteoclasts and activated macrophages express high amounts of type 5 tartrate-resistant acid phosphatase (TRACP; EC (1).
Tartrate-resistant acid phosphatase (TRACP) [4] has been advocated as a biomarker of osteoclastic activity with clinical value for assessment of bone resorption (6-8).
Serum band 5 tartrate-resistant acid phosphatase (TrACP 5 EC usually is expressed in certain differentiated cells of the mononuclear phagocyte system, notably osteoclasts and alveolar macrophages (1), and pathologically in Gaucher cells (2) and in the hairy cells of leukemia reticuloendotheliosis (3).