Key findings of this study included the upregulation of the IRF1, IL-6 and the TNF adapter protein TNFSF10 as well as the TNF receptor family members TRADD
and TRAF1 and the other known inflammation-related transcripts such as PTGS2, BCL2, and CCND1 on LPS stimulation.
A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD
and RIP to the TNF receptor 1 complex in Jurkat T cells.
Rehovot, Israel) has patented proteins capable of modulating or mediating the FAS receptor ligand or TNF effect on cells carrying FAS receptor or p55 receptor by binding or interacting with MORT-1 protein, which in turn binds to the intracellular domain of the FAS receptor or to another protein TRADD
which binds to the p55 receptor.
Patent 5,563,039 includes claims that encompass a novel protein, "TRADD
," which plays a key role in TNF signaling, nucleic acids encoding TRADD
and methods of use, including pharmaceutical screens.
NOX, NADPH oxidases; TNF-[alpha], tumor necrosis factor-a; EGF, epidermal growth factor; IL-1[beta], Interleukin-1[beta]; SOD, superoxide dismutase; GPx, glutathione peroxidase; GST-pi, glutathione S-transferase pi; MT3, metallothionein-3; FHC, ferritin heavy chain; DDH1, dihydrodiol dehydrogenase; TNFR, tumor necrosis factor receptor; TRADD
, TNFRSF1A-associated via death domain; MyD88, myeloid differentiation factor 88; TLR, Toll-like receptor; cPLA2, cytosolic phospholipases A2.
Asi mismo, la sobre-expresion de TRADD
y FADD en celulas 293 de rinon de embrion humano, aumenta significativamente la activacion de A-SMasa inducida por (TN[F.