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TRAF2TNF Receptor-Associated Factor 2
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76) One of these ER receptors, IRE1a, accounts for the pro-inflammatory potential of the UPR by recruiting TRAF2 to the ER membrane and thus the activation of NF-[kappa]B and the production of IL-6.
In addition, FBX07 binds to, and mediates ubiquitin conjugation to cIAP1 (cellular inhibitor of apoptosis protein 1) and TRAF2 (TNF receptor-associated factor 2), which leads to lowered activity of NF-[kappa]B (nuclear factor [kappa]B) (Kuiken et al.
They tested this discovery in 55 human samples of pancreatic cancer, and found that in 69 percent, TRAF2 wasn't functioning properly and there were higher levels of other molecules participating in the alternative pathway
TRADD then recruits TRAF2, RIP and other molecules, leading to the formation of the TNF-R1 signalling complex, downstream of NIK activation, NIK then phosphorylates IKK[alpha].
10-14,23] Finally, the overexpression of E2F-1 blocks antiapoptotic signal pathways such as NF[Kappa]-B and JNK/SAPK activation,[48] by down-regulating TRAF2 gene expression, a regulator of NFK-B and JNK/SAPK activity.
NF-[kappa]B antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and cIAP2 to suppress caspase-8 activation.
2] induced MMP-2 and MMP-9 expression in the lung adenocarcinoma cell line GLC-82, as well as of several components activated by the innate immune response including MyD88, TRAF2, TRAF6, and TRADD [95].