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TRAF6Tumor Necrosis Factor Receptor-Associated Factor 6 (protein)
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References in periodicals archive ?
Bowie, "IRAK-2 participates in multiple Toll-like receptor signaling pathways to NF[kappa]B via activation of TRAF6 ubiquitination," The Journal of Biological Chemistry, vol.
CYLD deubiquitylates TRAF6, which transduces the RANK-mediated signal [99].
In order to investigate the relevance of the hub genes and NS, the expression levels of PIK3CA, TGFBR2, CDKN1B, KRAS, E2F3, TRAF6, and CHUK were further analyzed.
(2014) NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6. Mucosal Immunol.
First description and expression analysis of tumor necrosis factor receptor-associated factor 6 (TRAF6) from the swimming crab, Portunus trituberculatus.
MyD88 activates TNF receptor-associated factor 6 (TRAF6), which stimulates the IKB kinase (IKK) complex; consequently, phosphorylated nuclear transcription factor (NF-KB) translocates from the cytoplasm to the nucleus (Turner et al., 2012).
Antonioli et al., "mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6," Nature Cell Biology, vol.
In sepsis induced cardiac injury and dysfunction, miR-146a can attenuate NF-kB dependent inflammatory signaling by targeting IRAK and TRAF6 in cardiomyocytes and monocytes [155].
pylori are associated with cell cycle progression and proliferation (p14, p16, p21, p27, RAB40C, COX 2, FOS, ERBB2, FGFR2, ABL1, ECOP, JAK2, MYC, MET, SIRT1, PDCD4, TRAF6, GMNN, and CCNE2) [213, 223-242], apoptosis (RECK, SMAD4, TRAIL, MCL1, BIM, XIAP, and PDK1) [243-250], and invasion and metastasis (pTEN, WNT 5a, EDNRA, ROR2, EPB41L3, MMP1, MMP10, HMGA2, ROBO1, TGF-[beta], EZH2, casein kinase 2, and ZEB) [251-262].
Akatsuka et al., "Receptor activator of NF-[kappa]B ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6," Molecular and Cellular Biology, vol.
Extracellularly secreted IL-33 binds to ST2 and activates a heterodimeric receptor complex, comprising ST2 andinterleukin-1 receptor accessory protein (IL-1RAcP) on the plasma membrane, to recruit and activate myeloid differentiation factor 88 (MyD88), followed by activation of interleukin-1 receptor-associated kinase (IRAK) and tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) [5] (Figure 1).
Interestingly, miR-146 is a negative regulator of astrocytemediated inflammation [82], and upregulation of this miRNA decreases the expression of its target TRAF6 that is linked to seizure frequency in glioma patients suggesting that miR-146 could be involved in the epileptogenic focus surrounding the tumor [81].