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TRF2TBP-Related Factor 2
References in periodicals archive ?
Statins enhance migratory capacity by upregulation of the telomere repeatbinding factor TRF2 in endothelial progenitor cells," Circulation, vol.
The Ser245Tyr mutation lies outside of this mutation cluster and also outside of the binding regions of TINF2 to TRF1, TRF2, and TPP1.
A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins," Science, vol.
Because TRF2 and GAPDH are both involved in the regulation of telomere homeostasis, the aim of this study was to determine if there was a correlation between the expression of these genes in primary cell cultures of ovarian surface epithelium, using qRT-PCR.
Because TRF2 and GAPDH had the same thermal profile, the corresponding cDNA samples were amplified simultaneously and in duplicate for each experiment.
The melting curves verified the existence of a single fluorescence peak at each concentration, confirming the specificity of the primers and therefore the exclusive amplification of the TRF2 and GAPDH gene products.
Increased expression of telomere length regulating factors TRF1, TRF2 and TIN2 in patients with adult T-cell leukemia.
Viewed under an electron microscope, telomeres exposed to TRF2 often displayed large circles, which the researchers named t loops, but no single-stranded ends.
Cells lacking TRF2 activate DNA-repair machinery and sometimes even commit suicide, suggesting that telomeres require TRF2 to form loops, says de Lange.
Unipex Innovations; and "Role of TRF2 in Preventing Cellular Senescence and Associated Skin Damages,"Isabellc Imbert, Ph.
2 TUBO BISK WROC GOPE ZYWI TRF2 velocity (mm/y) -0.