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Sahun et al., "Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction," Neurobiology of Disease, vol.
Groppi et al., "The detection of Tel-TrKC chimeric transcripts is more specific than TrkC immunoreactivity for the diagnosis of congenital fibrosarcoma," Journal of Pathology, vol.
Belluardo, "Increased expression of trkB and trkC messenger RNAS in the rat forebrain after focal mechanical injury," Neuroscience, vol.
In this study, we investigated the effects of treadmill exercise on the expression of NT-3 and trkC in a rat model of experimental cerebral infarction.
Distinct steps of neural induction revealed by asterix, obelix and TrkC, genes induced by different signals from the organizer.
They include the nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophins 3 and 4/5 (NT3 and NT4/5), which function through two different types of receptors, namely, tyrosine kinase (Trk) (i.e., TrkA for NGF, TrkB for BDNF and NT4, and TrkC for NT3) and p75 receptors.
By studying human neuroblastoma cells in vitro and after xenotransplantation into mice and chicks, a team of researchers, led by Patrick Mehlen, at Universite de Lyon, France, has identified the protein NT-3 and the cell-surface molecule to which it binds (TrkC).
Voluntary exercise increases neurotrophin-3 and its receptor TrkC in the spinal cord.
The presence of neurotrophins and the neurotrophin receptors p75 (p75NTR), tyrosine kinase A (TrkA), TrkB and TrkC are present in several immune cells.