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In this study, we investigated the effects of treadmill exercise on the expression of NT-3 and
trkC in a rat model of experimental cerebral infarction.
Distinct steps of neural induction revealed by asterix, obelix and
TrkC, genes induced by different signals from the organizer.
They include the nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophins 3 and 4/5 (NT3 and NT4/5), which function through two different types of receptors, namely, tyrosine kinase (Trk) (i.e., TrkA for NGF, TrkB for BDNF and NT4, and
TrkC for NT3) and p75 receptors.
By studying human neuroblastoma cells in vitro and after xenotransplantation into mice and chicks, a team of researchers, led by Patrick Mehlen, at Universite de Lyon, France, has identified the protein NT-3 and the cell-surface molecule to which it binds (
TrkC).
Voluntary exercise increases neurotrophin-3 and its receptor
TrkC in the spinal cord.
The presence of neurotrophins and the neurotrophin receptors p75 (p75NTR), tyrosine kinase A (TrkA), TrkB and
TrkC are present in several immune cells.
Relatives of trk are receptors for other neurotrophic factors--trkB seems to be a receptor for brain-derived neurotrophic factor, and
trkC for neurotrophin-3.