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"AITC and many other irritants found in roots -- one of the mole-rat's main food sources -- activate TRPA1," explains Lewin.
The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives.
TRPA1 antagonists are part of the Transient Receptor Potential family of ion channels, currently being studied for the potential treatment of chronic pain syndromes.
Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs.
Hereby, we stress on the fact that TRPA1 is a critical sensor of stress and tissue injury as well as a multi-purpose sensor of deleterious signals.
Li, "Transient receptor potential vanilloid-1 (TRPV1) and ankyrin-1 (TRPA1) participate in visceral hyperalgesia in chronic water avoidance stress rat model," Neurochemical Research, vol.
Higashikawa et al., "High pH-sensitive TRPA1 activation in odontoblasts regulates mineralization," Journal of Dental Research, vol.
Other Possible Therapeutic Targets: Transient Receptor Potential Ankyrin-1 (TRPA1) and Transient Receptor Potential Melastatin-8 (TRPM8)?
Khakh, "TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release," The Journal of Neuroscience, vol.
C fibers mostly conduct nociceptive signals but also function as chemoreceptors in response to signals from transient receptor potential cation channel, subfamily A, member 1 (TRPA1), and transient receptor potential cation channel, subfamily V, member 1 (TRPV1), among others .
Cortright, "Increased TRPA1, TRPM8, and TRPV2 expression in dorsal root ganglia by nerve injury," Biochemical and Biophysical Research Communications, vol.
Yamamoto, "Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine," American Journal of Physiology-Gastrointestinal and Liver Physiology, vol.
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- Troyer syndrome
- Troyes, France
- Troyes, France
- Troyes, Treaty of
- Troyon, Constant
- TRP III