mediates the noxious effects of natural sesquiterpene deterrents.
The Glenmark TRPA1
program includes indications in pain as well as respiratory.
Lead author of the study, Dr Jordana Bell, Department of Twin Research and Genetic Epidemiology at King's College London, said that the potential to epigenetically regulate the behaviour of TRPA1
and other genes involved in pain sensitivity is very exciting and could lead to a more effective pain relief treatment for patients suffering with chronic pain.
4]; PD1, 10R,17S-dihydroxy-4Z,7Z,11E,13E,15Z,19Z- docosahexaenoic acid; Rt, retention time; [M-1], molecular ion--1 mass unit; RvE1, 5S,12R,18R- trihydroxy-6Z,8E,10E,14Z,16E- eicosapentaenoic acid; RvE2, 5S,18R-dihydroxy6E,8Z,11Z,14Z,16E- eicosapentaenoic acid; TRPA1
, transient receptor potential ankyryn 1.
Research groups are now testing molecules that block TRPA1
, mostly with the idea of developing pain drugs.
Distribution and function of the hydrogen sulfide-sensitive TRPA1
ion channel in rat urinary bladder.
Pungent products from garlic activate the sensory ion channel TRPA1
5 Modulator Project II-27 Aurora Biomed Inks Agreement with Specs and Alion Pharmaceuticals II-27 Hydra and Zalicus Enter into Partnership II-27 Hydra Biosciences and Cubist Pharmaceuticals to Commence Phase 1 Clinical Trial for TRPA1
Antagonist CB-625 II-27 Vertex Pharmaceuticals Receives USFDA Approval for KALYDECO(TM) II-27 6.
E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-l ,6-heptadiene-3,5-dione) activates and desensitizes the nociceptor ion channel TRPA1
Spinal 12-lipoxygenase-de-rived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1
Xu found that cold air activates a receptor known as the TRPA1
channel, found in nerve and fat cells in nematodes, and TRPA1
then passes calcium into cells.
Cigarette smoke-induced neurogenic inflammation is medicated by [alpha], [beta]-unsaturated aldehydes and the TRPA1
receptor in rodents.