dimethyl sulfoxide; L-NAME, N(G)-nitro-L-arginine methyl ester; NO, nitric oxide; PDE, phosphodiesterase; SERCA, sarco/endoplasmic reticulum [Ca.sup.2+]-ATPase; TRP, transient receptor potential: TRPC
, canonical-type TRP; TRPM, melastatin-type TRP; TRPV.
Kurose, "Mechanism of cardiac hypertrophy via diacylglycerol-sensitive TRPC
channels," Yakugaku Zasshi, vol.
In addition, we propose that TRPC
channels are involved in analgesia, because TRPC7(-/-) mice have no pain sensitivity (unpublished data).
It has been reported that kisspeptin potently depolarizes GnRH neurons primarily through the activation of canonical transient receptor potential channels (TRPC
(131-134) Astrocytes ubiquitously express several isoforms of TRPC
channels, of which heteromers assembled from TRPC1, 4 and/or 5 subunits likely act as stretch-activated channels.
subfamily has seven members (TRPC1-7) [49-51].
(2005) Orexin-A-induced Ca2+ entry: evidence for involvement of trpc
channels and protein kinase C regulation.
(a) Genetically encoded light-sensitive (top, ChR) or temperature-sensitive (bottom, TRPC
) cation channels can be expressed in cell membrane, which can response to direct light illumination (optogenetics) or indirect heat generated by light (thermogenetics).
Essential role of TRPC
channels in the guidance of nerve growth cones by brain-derived neurotrophic factor.
The transient receptor potential cation channel (TRPC
) gene, which was first cloned in Drosophila , encodes a light-activated ion channel in photoreceptors.
A major component of Socs is the transient receptor potential channel (TRPC
) protein TRPC1 .