Arachidonic acid and its breakdown products and/or compounds, including arachidonic acid, stimulate mammalian TRPC6, several isoforms of mammalian TRPV and TRPM, as well as Drosophila TRP and TRPL channels (Chyb et al.
Activation of TRPC6 calcium channels by diacylglycerol (DAG)-containing arachidonic acid: a comparative study with DAG-containing docosahexaenoic acid.
Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol.
The most common cause of the autosomal dominant FSGS is the INF2 gene mutations (16%), followed by mutations in the TRPC6
(12%) and the ACTN4 (3.
contributes to the Ca(2+) leak of human erythrocytes.
About half of the patients don't survive for more than a year after their diagnosis And thus the role of TRPC6 discovered at UCF is so promising.
Collectively, our studies indicate that TRPC6 is a key mediator of tumor growth of GBM.
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function.
Induction of TRPC6 channel in acquired forms of proteinuric kidney disease.
7 Several other genes, including WT1, TRPC6
, and ACTN4, have been implicated in the causation of NS in children and adolescents.