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TRPC6Transient Receptor Potential Channel 6
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The team has found that in cells containing the same TRPC6 fault as some patients with nephrotic syndrome, this anchor is lost, directly affecting the kidney's filter because it makes podocytes sticky and unable to move.
Regarding the changes in mRNA of particular interest were (i) downregulation of Gja5 and Gjd3 (4-fold), (ii) downregulation of Trpc6 (6-fold), (iii) downregulation of Hcn4 (5-fold), (iv) downregulation of Cacna1d (3-fold), Cacna1h (4-fold), and Cacng4 (3-fold), (v) downregulation of Kcna5 (5-fold) and Kcnk1 (7-fold) in GK compared to control SAN, and (vi) upregulation of Nppb in GK compared to control SAN.
Arachidonic acid and its breakdown products and/or compounds, including arachidonic acid, stimulate mammalian TRPC6, several isoforms of mammalian TRPV and TRPM, as well as Drosophila TRP and TRPL channels (Chyb et al., 1999; Watanabe et ai, 2003; Aires et al., 2007; Meves, 2008).
Payet, "20-hydroxyeicosatetraenoic acid (20-HETE) activates mouse TRPC6 channels expressed in HEK293 cells," The Journal of Biological Chemistry, vol.
Han, "Down-regulation of SENCR promotes smooth muscle cells proliferation and migration in db/db mice through up-regulation of FoxO1 and TRPC6," Biomedicine and Pharmacotherapy, vol.
The most common cause of the autosomal dominant FSGS is the INF2 gene mutations (16%), followed by mutations in the TRPC6 (12%) and the ACTN4 (3.5%) genes.
Mutational analysis of seven podocyte genes (NPHS1, NPHS2, WT1, CD2AP, ACTN4, TRPC6 and PLCE1) in 19 non-familial childhood-onset, steroid resistant, biopsy-proven FSGS patients revealed variants of NPHS1, NPHS2, WT1 and CD2AP that could be the cause of the disease in four subjects (21%).
Lynn et al., "Medicine: a mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis," Science, vol.
Activation of these receptors via PLC-[beta] pathway results in activation of TRPC6. Increased activity of TRPC6 and thus intracellular calcium causes changes in actin cyto-skeleton and FSGS [72].
Its mammalian homologs constitute a superfamily of cation channels which comprises 6 subtypes (TRPC1 to TrPC6) 18, 21].
The molecular identity of the [Ca.sup.2+] permeable erythrocyte cation channels is still illdefined but presumably involves the transient receptor potential channel TRPC6 (Foller et al.