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The TRPM inhibitor AMTB hydrochloride (Lashinger et al.
The highest similarities and coverage were found with TRPM, TRPP, and TRPML query sequences.
BLASTP analysis identified TRPM, TRPP, and TRPML-like proteins in Lingulodinium polyedra.
We identified the TRP domain, shared between mammalian TRPM and TRPC as well as Caenorhabditis elegans TRPN, Danio rerio TRPN, Drosophila TRPM, TRP[gamma], and TRPL, and Chlamydomonas reinhardtii TRP1 (Venkatachalam and Montell, 2007; Latorre et al.
Phylogenetic inference of the six-transmembrane domain including Lp1-Lp6 and selected TRP family members from Homo sapiens (Hs), Danio rerio (Dr), Drosophila melanogaster (Dm), Caenorhabditis elegans (Ce), Monosiga brevicollis (Mb), Paramecium tetraurelia (Pt), and Chlamydomonas reinhardtii (Cr) places Lp1 and Lp2 in the TRPM clade, Lp3-Lp5 in the TRPP clade, and Lp6 in the TRPML clade (Fig.
Arachidonic acid and its breakdown products and/or compounds, including arachidonic acid, stimulate mammalian TRPC6, several isoforms of mammalian TRPV and TRPM, as well as Drosophila TRP and TRPL channels (Chyb et al.
polyedra, including compounds directed against mammalian TRP subfamilies TRPV, TRPM, and TRPC, as well as general inhibitors of mechanosensitive ion channels (Table 1).
Carvacrol, which inhibits mammalian TRPM and Drosophila TRPL (Parnas et al.
We also screened the effect of the TRPV inhibitor RN1734, the TRPV and TRPM inhibitor HC067047, the TRPV and TRPC inhibitor SKF 96365, and the general mechanosensing ion channel inhibitor GsMTx4 on stirring-induced luminescence.
BLASTP and phylogenetic inference indicate that Lingulodinium polyedra expresses TRPM (Lp1 and Lp2)-like, TRPP (Lp3-Lp5)-like, and TRPML (Lp6)-like proteins.
There are few reports of TRPM channels in unicellular organisms.
polyedra have the potential to be involved in mechanosensing; channels belonging to the TRPM and TRPP families are described in shear stress and stretch-sensing signaling pathways of mammalian endothelial cells and vascular smooth muscle cells, as well as in sensing of light touch in Drosophila larvae (Earley et al.
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