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Table 2 Results of BLASTP analysis BLASTP query sequence Lingulodinium polyedra ORF e-value Hs TRPM2 (NP_003298.
24) The TRPM2 channel was the first redox-sensitive TRP channel to be identified.
93) Other redox-sensitive TRPs (TRPC1, TRPC4, TRPM2 and TRPM7) (47) that by themselves do not respond to reactive disulphides including 5-nitro-2PDS (10 [micro]M) failed to respond to hyperoxia.
2005) TRPM2 and TRPM7: channel/enzyme fusions to generate novel intracellular sensors.
2005) Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels.
A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death.
Novel role for the transient receptor potential channel TRPM2 in prostate cancer cell proliferation.
Identification of novel sense and antisense transcription at the TRPM2 locus in cancer.
phox]: Regulatory subunits of NOX2 PLA2: Phospholipase A2 Rac1: Ras-related C3 botulinum toxin substrate 1 acting as regulatory subunits of NOX2 Rho: A small prokaryotic protein involved in the termination of transcription ROS: Reactive oxygen species RyR: Ryanodine receptor RyR1: Ryanodine receptor type 1 SOD: Superoxide dismutase TRP: Transient receptor potential channel with isoforms TRPM2, TRPM7, TRPC5, TRPV1, TRPV2, TRPV3, TRPV4, TRPA1, and TRPM8 XO: Xanthine oxidase X-ROS: Stretch activated ROS production by NOX2 to potential calcium signaling.
ROS-induced TRPM2 channel activation most probably occurs indirectly via formation of adenosine diphosphate ribose (ADPR) which activates the channel by binding to a special domain located at the C-terminus of the channel .
In addition, mRNA data of hematopoietic and lymphoid tissue cancer cell lines of the Novartis and Broad Institute Cancer Cell Line Encyclopedia were queried for TRPM2 and Bcl-2 mRNA abundance.
Shortly before transfection, TRPM2 or nontargeting siRNA was added at a concentration of 1 [micro]M.
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