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Fleig, "TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions," The Journal of General Physiology, vol.
Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation, migration and invasion.
TRPM7, characterized by its unique "chanzyme" structure comprising a kinase domain as well as a transmembrane ion channel pore permeable to cations such as [Ca.sub.2+], [Mg.sup.2+], [Ni.sup.2+], [Zn.sup.2+] and trace metals, (37-39) has been suggested to have general biological importance shared by different types of cells.
Rui, "Neuroprotective role of microRNA-22 in a 6-hydroxydopamine-induced cell model of Parkinson's disease via regulation of its target gene TRPM7," Journal of Molecular Neuroscience, vol.
Shi et al., "Involvement of TRPM7 in cell growth as a spontaneously activated Ca2+ entry pathway in human retinoblastoma cells," Journal of Pharmacological Sciences, vol.
Singh, "TRPM7 and its role in neurodegenerative diseases," Channels (Austin, Texas), vol.
Zheng et al., "TRPM7 channel inhibition mediates midazolam-induced proliferation loss in human malignant glioma," Tumor Biology, vol.
Abed and Moreau (9) also demonstrated that the influx of Mg ions enhanced cell migration and stimulated the gene expression of TRPM7 channels in human osteoblast MG-63 cells.
There is also a intracellular [Ca.sup.2+] release-activated [Ca.sup.2+] current in microglia that appears to be regulated by Ora1 and TRP channels, particularly TRPM7 .
Liu et al., "Decreased TRPM7 inhibits activities and induces apoptosis of bladder cancer cells via ERK1/2 pathway," Oncotarget, vol.
Transient receptor potential melastatin-like 7 channel (TRPM7) is a member of melastatin-like transient receptor potential (TRPM) subfamilies, widely expressed in mammalian cells .
Wu, "The effect of TRPM7 suppression on the proliferation, migration and osteogenic differentiation of human dental pulp stem cells," International Endodontic Journal, vol.
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