The highest similarities and coverage were found with TRPM, TRPP, and TRPML query sequences.
BLASTP analysis identified TRPM, TRPP, and TRPML-like proteins in Lingulodinium polyedra.
The longer AA distance is characteristic for TRPML and TRPP in other organisms (Venkatachalam and Montell, 2007).
Phylogenetic inference of the six-transmembrane domain including Lp1-Lp6 and selected TRP family members from Homo sapiens (Hs), Danio rerio (Dr), Drosophila melanogaster (Dm), Caenorhabditis elegans (Ce), Monosiga brevicollis (Mb), Paramecium tetraurelia (Pt), and Chlamydomonas reinhardtii (Cr) places Lp1 and Lp2 in the TRPM clade, Lp3-Lp5 in the TRPP clade, and Lp6 in the TRPML clade (Fig.
BLASTP and phylogenetic inference indicate that Lingulodinium polyedra expresses TRPM (Lp1 and Lp2)-like, TRPP (Lp3-Lp5)-like, and TRPML (Lp6)-like proteins.