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TRPV4 forms a DEP-sensitive [Ca.sup.2+] pathway downstream of PI3-K/PLC-[beta]3.
The Anabolic Effect of Low-Magnitude Compression Is Inhibited by Inhibiting the Transient Receptor Potential Vanilloid 4 (TRPV4) Channel.
Additional mechanisms include structural and functional abnormalities of mitochondria, free radical-mediated oxidative stress, molecular transport by cation channeling (TRPV4), vitamin uptake (SLC52A3 and SLC52A2), nuclear transport (GLE1), lipid metabolism (ASAH1), and axonal transport (BICD2 and DYNC1H1).
For instance, TRPV4 expressed in skin keratinocytes functions as a pruriceptor, mediating the histaminergic itch and scratching behavior .
Yu et al., "TRPV4 channel inhibits TGF[beta]1- induced proliferation of hepatic stellate cells," PLoS ONE, vol.
The researchers said that those phenomena were almost completely attributed to TRPV4 activation, since such responses were eliminated by a TRPV4 inhibitor and reduced in TRPV4-deficient urothelial cells.
TRPV4 enhances cellular uptake of aminoglycoside antibiotics.
PMP22, MPZ, MFN2, GDAP1, NEFL, CX32, MYH14, LMNA, TRPV4, LITAF.
Engel, "Differential contribution of TRPA1, TRPV4 and TRPM8 to colonic nociception in mice," PLoS One, vol.
The underlying mechanotransduction mechanism of transient receptor potential vanilloid 4 (TRPV4) was also investigated.
In this case, TRP channels of soft touch receptors would induce [Ca.sup.2+] influx by activation of TRPC7, TRPV4, TRPM3, and TRPP, all of which have a high conductance (about 100 pS) for [Ca.sup.2+].
Furthermore, PAR4 activation has been demonstrated to reverse the PAR2 or transient receptor potential vanilloid-4 (TRPV4) activation that is evoked in colorectal hypersensitivity .
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