TRPV4

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Acronym	Definition
TRPV4	Transient Receptor Potential Vanilloid 4 (cation channel)

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References in periodicals archive ?

TRPV4 forms a DEP-sensitive [Ca.sup.2+] pathway downstream of PI3-K/PLC-[beta]3.

TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles

The Anabolic Effect of Low-Magnitude Compression Is Inhibited by Inhibiting the Transient Receptor Potential Vanilloid 4 (TRPV4) Channel.

Low Magnitude of Compression Enhances Biosynthesis of Mesenchymal Stem Cells towards Nucleus Pulposus Cells via the TRPV4-Dependent Pathway

Additional mechanisms include structural and functional abnormalities of mitochondria, free radical-mediated oxidative stress, molecular transport by cation channeling (TRPV4), vitamin uptake (SLC52A3 and SLC52A2), nuclear transport (GLE1), lipid metabolism (ASAH1), and axonal transport (BICD2 and DYNC1H1).

Inherited Paediatric Motor Neuron Disorders: Beyond Spinal Muscular Atrophy

For instance, TRPV4 expressed in skin keratinocytes functions as a pruriceptor, mediating the histaminergic itch and scratching behavior [320].

Extraoral Taste Receptor Discovery: New Light on Ayurvedic Pharmacology

Yu et al., "TRPV4 channel inhibits TGF[beta]1- induced proliferation of hepatic stellate cells," PLoS ONE, vol.

Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases

The researchers said that those phenomena were almost completely attributed to TRPV4 activation, since such responses were eliminated by a TRPV4 inhibitor and reduced in TRPV4-deficient urothelial cells.

Molecular mechanism that lets bladder feel fullness of urine uncovered

TRPV4 enhances cellular uptake of aminoglycoside antibiotics.

The aminoglycoside antibiotic gentamicin is able to alter metabolic activity and morphology of MDCK-C11 cells: a cell model of intercalated cells

PMP22, MPZ, MFN2, GDAP1, NEFL, CX32, MYH14, LMNA, TRPV4, LITAF.

Role of Alpha-methylacyl-CoA racemase gene in pathogenecity of CMT patients

Engel, "Differential contribution of TRPA1, TRPV4 and TRPM8 to colonic nociception in mice," PLoS One, vol.

A Novel Model of Cancer-Induced Peripheral Neuropathy and the Role of TRPA1 in Pain Transduction

The underlying mechanotransduction mechanism of transient receptor potential vanilloid 4 (TRPV4) was also investigated.

Stem Cells in Cartilage Diseases and Repair 2018

In this case, TRP channels of soft touch receptors would induce [Ca.sup.2+] influx by activation of TRPC7, TRPV4, TRPM3, and TRPP, all of which have a high conductance (about 100 pS) for [Ca.sup.2+].

A Proposed Molecular Mechanism for Physical Analgesia in Chronic Pain

Furthermore, PAR4 activation has been demonstrated to reverse the PAR2 or transient receptor potential vanilloid-4 (TRPV4) activation that is evoked in colorectal hypersensitivity [8].

Downregulation of iNOS, IL-1[beta], and P2X7 Expression in Mast Cells via Activation of PAR4 Contributes to the Inhibition of Visceral Hyperalgesia in Rats