TRPV4

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Acronym	Definition
TRPV4	Transient Receptor Potential Vanilloid 4 (cation channel)

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References in periodicals archive ?

polyedra was stimulated by RN1747, an activator of mammalian TRPV4 channels with a yet-unknown mechanism of action (Vincent et al.

Role of TRP Channels in Dinoflagellate Mechanotransduction

128-130) Also, TRPV4 channels in astrocytes are activated following osmotic challenges and are up-regulated in ischaemic conditions.

TRP channels in oxygen physiology: distinctive functional properties and roles of TRPA1 in [O.sub.2] sensing

For instance, low permeability can lead to cellular swelling and produce 5,6-Epoxyeicosatrienoic acid (5,6-EET) to directly activate TRP protein super-family members' sensitivity to mechanical factors such as TRPV4 and TRPA1.

Mechanism of TRPA1 and TRPV4 participating in mechanical hyperalgesia of rat experimental knee osteoarthritis

Hydrogen peroxide-induced calcium influx in lung microvascular endothelial cells involves TRPV4," American Journal of Physiology--Lung Cellular and Molecular Physiology, vol.

Molecular and Cellular Effects of Hydrogen Peroxide on Human Lung Cancer Cells: Potential Therapeutic Implications

Mutations in the gene encoding the calcium-permeable ion channel TRPV4 produce spondylometaphyseal dysplasia, Kozlowski type and metatropic dysplasia.

A case of metatropic dysplasia: operative treatment of severe kyphoscoliosis and limb deformities

These findings suggest that TRPV4 blockers could be used to limit pulmonary edema in patients with heart or lung disease, and were an important step toward validating the lung on a chip model," said Thorneloe, whose companion study was published in the same journal.

Scientists test drugs on tiny, artificial lung

TRPV4 is gated by mechanical streteh, arachidonic acid metabolites, heat and the synthetic phorbol ester, 4a-phorbol 12, 13-didecanoate (4[alpha]PDD).

Biological Sciences paper Abstracts

Last week, Ember announced that it has secured an exclusive option to license a TRPV4 program that was recently the subject of a Cell publication that highlights the importance of this specific channel in brown fat biology.

Ember Therapeutics Broadens Brown Fat Small Molecule Drug Discovery Portfolio, Secures Exclusive License Options to Intellectual Property for Three Small Molecule Targets

The blockage of the channel with ruthenium red (a nonspecific TRPV4 channel blocker) or TRPV4 silencing inhibited the proliferation of TGF-[beta]1-treated HSCT6 cells and decreased profibrotic marker expression.

Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases

This hypothesis has not yet been demonstrated, but it is supported by the finding that AQP4 or -5 can interact with the volume-sensitive calcium channel TRPV4 in mouse astrocytes and salivary glands for the regulation of cell volume under hypotonic stimulation (Liu et al.

Aquaporin biology of spermatogenesis and sperm physiology in mammals and teleosts

Blocking this molecule, called TRPV4, greatly protects against the painful effects of sunburn.

New findings could make sunburns history

2+]-permeable TRPV4, which leads to activation of human respiratory disease--enhancing matrix metalloproteinase-1 (MMP-1), a signaling cascade initiated by diesel exhaust particles (DEP), a globally relevant air pollutant.

TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles