Unlike hematopoietic cytokines, epithelial-derived cytokines, namely, IL-25,
TSLP, and IL-33, are released when airway epithelium is exposed to allergens, fungi, and viral antigens (Figure 2) [59].
Johansen et al., "
TSLP, IL-31, IL-33 and sST2 are new biomarkers in endophenotypic profiling of adult and childhood atopic dermatitis," Journal of the European Academy of Dermatology and Venereology, vol.
(2014) induce IL-33,
TSLP and /USA (16) generate IL-13 dependent airway inflammation Sultana et Investigation of Science of the al.
Based on this immunological background, various novel antiasthma drugs targeting type 2 immune mediators--interleukin(IL-) 4, IL-5, IL-13,
TSLP, IL-33, and CRTH2--are now under development [5].
ACM Transactions on Speech and Language Processing (
TSLP) 9(1): 1-23.
Disruption of the skin barrier activates the adaptive immune alarm system; several cytokines have been identified in this process, including interleukin (IL)-33, thymic stromal lymphopoietin (
TSLP), IL-25, toll-like receptors, and other inflammasome-activating signals.
Other pharmacologic targets currently being investigated include inhibitors of
TSLP. chemoattractant receptor-homologous molecule expressed on [T.sub.H]2 cells (CR[T.sub.H]2), IL-13 alone, IL-22, and immunoglobulin E.
He believes pollen, dust mites and similar allergens trigger the protein thymic stromal lymphopoietin (
TSLP), which is produced by cells called keratinocytes in the skin's outermost layer.
* Turnaround School Leaders Program (
TSLP) Grants: $16.3 million for eight grantees to develop and implement or enhance and implement a leadership pipeline that selects, prepares, places, supports, and retains school leaders or leadership teams at low-performing schools.
In addition, Th2-oriented cytokine such as human
TSLP (thymic stromal lymphopoietin) that can be released by bronchial epithelial cells and is over-expressed in asthmatic patients was shown to augment the expression of CD80 on circulating monocytes.
Most recently, thymic stromal lymphopoietin (
TSLP) has been shown to contribute to the pathogenesis of asthma and treatment of asthmatic patients with a monoclonal antibody directed against
TSLP improves respiratory function [6].