Unlike hematopoietic cytokines, epithelial-derived cytokines, namely, IL-25, TSLP
, and IL-33, are released when airway epithelium is exposed to allergens, fungi, and viral antigens (Figure 2) .
Johansen et al., "TSLP
, IL-31, IL-33 and sST2 are new biomarkers in endophenotypic profiling of adult and childhood atopic dermatitis," Journal of the European Academy of Dermatology and Venereology, vol.
(2014) induce IL-33, TSLP
and /USA (16) generate IL-13 dependent airway inflammation Sultana et Investigation of Science of the al.
Based on this immunological background, various novel antiasthma drugs targeting type 2 immune mediators--interleukin(IL-) 4, IL-5, IL-13, TSLP
, IL-33, and CRTH2--are now under development .
ACM Transactions on Speech and Language Processing (TSLP
) 9(1): 1-23.
Disruption of the skin barrier activates the adaptive immune alarm system; several cytokines have been identified in this process, including interleukin (IL)-33, thymic stromal lymphopoietin (TSLP
), IL-25, toll-like receptors, and other inflammasome-activating signals.
Other pharmacologic targets currently being investigated include inhibitors of TSLP
. chemoattractant receptor-homologous molecule expressed on [T.sub.H]2 cells (CR[T.sub.H]2), IL-13 alone, IL-22, and immunoglobulin E.
He believes pollen, dust mites and similar allergens trigger the protein thymic stromal lymphopoietin (TSLP
), which is produced by cells called keratinocytes in the skin's outermost layer.
* Turnaround School Leaders Program (TSLP
) Grants: $16.3 million for eight grantees to develop and implement or enhance and implement a leadership pipeline that selects, prepares, places, supports, and retains school leaders or leadership teams at low-performing schools.
In addition, Th2-oriented cytokine such as human TSLP
(thymic stromal lymphopoietin) that can be released by bronchial epithelial cells and is over-expressed in asthmatic patients was shown to augment the expression of CD80 on circulating monocytes.
Most recently, thymic stromal lymphopoietin (TSLP
) has been shown to contribute to the pathogenesis of asthma and treatment of asthmatic patients with a monoclonal antibody directed against TSLP
improves respiratory function .