Because of the tSNP methodology, we have no means of identifying functional SNPs on hGTATA, and the task has added difficulty given the high degree of LD between the tSNPs and other SNPs within the gene.
[6] Nonstandard abbreviations: IL, interleukin; IL-18BP, IL-18 binding protein; CHD, coronary heart disease; CUDAS, Carotid Ultrasound Disease Assessment Study; CUPID, Carotid Ultrasound in Patients with Ischaemic Heart Disease; IMT, intima-media thickness; IIPGA, Innate Immunity PGA; IMT, intima-medial wall thickness; tSNP, tagging single-nucleotide polymorphism; SNP, single-nucleotide polymorphism; HWE, Hardy-Weinberg equilibrium; LD, linkage disequilibrium; hGTATA, GTATA haplotype; hTTATC, TTATC haplotype.
The 5 IL18 tSNPs genotyped here were not the same as those used by Tiret et al.