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(i) Tagging single-nucleotide polymorphisms (tSNPs) of the endoplasmic reticulum aminopeptidase (ERAP) 1 and 2 is associated with baseline systolic and diastolic blood pressure (BP).
As described previously (20, 21), we implemented a 2-stage approach for choosing haplotype-tagging single-nucleotide polymorphisms (tSNPs) for genotyping.
Location and allele frequencies of genotyped tSNPs in TNF and IL6 genes in controls.
Because of the tSNP methodology, we have no means of identifying functional SNPs on hGTATA, and the task has added difficulty given the high degree of LD between the tSNPs and other SNPs within the gene.
 Nonstandard abbreviations: IL, interleukin; IL-18BP, IL-18 binding protein; CHD, coronary heart disease; CUDAS, Carotid Ultrasound Disease Assessment Study; CUPID, Carotid Ultrasound in Patients with Ischaemic Heart Disease; IMT, intima-media thickness; IIPGA, Innate Immunity PGA; IMT, intima-medial wall thickness; tSNP, tagging single-nucleotide polymorphism; SNP, single-nucleotide polymorphism; HWE, Hardy-Weinberg equilibrium; LD, linkage disequilibrium; hGTATA, GTATA haplotype; hTTATC, TTATC haplotype.
The 5 IL18 tSNPs genotyped here were not the same as those used by Tiret et al.
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