TSP1Test Synchronization Protocol 1 (also seen as TSP1+)
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Kim et al., "The aberrant methylation of TSP1 suppresses TGF-[beta]1 activation in colorectal cancer," International Journal of Cancer, vol.
The present study aimed to measure the levels of TSP1, MMP9/NGAL, and total MMP9 in GCF 1h before and after 1, 4, 8, 24, and 72 hours, 1 and 2 weeks from the orthodontic activation in the situation of a good control of the bacterial plaque, to determine the relationship between them and their implication in angiogenesis balance in PDL especially for MMP9/NGAL and TSP1.
[2] Nonstandard abbreviations: EDRN, EarlyDetection Research Network; NCI, National Cancer Institute; HUPO, Human Proteome Organisation; MS, mass spectrometry; TSP1, thrombospondin 1; EPCA-2, early prostate cancer antigen-2; proPSA, prostate-specific antigen precursor; CA125, cancer antigen 125; DCP, des-y carboxyprothrombin; AFP, [alpha]-fetoprotein; HCC, hepatocellular carcinoma; HE4, human epididymis protein 4.
Through cell culture and mouse experiments, the researchers found that a protein called thrombospondin-1 (TSP1) and its receptor, CD47, inhibit activation of the endothelial-based enzyme called endothelial nitric oxide synthase (eNOS), which in turn limits the production of NO and thus prevents blood vessels from relaxing and blood pressure from dropping.
De igual forma se reconocieron genes que regulados por p53 eran capaces de generar sustancias antiangiogenicas como la trombospondina 1 (TSP1) (44).
Li, 17, found that nitric oxide, which normally inhibits blood vessel growth, stimulates growth in vessels supporting tumors if a protein called thrombospondin-1 (TSP1) is present.
The leucine-serine-lysine-leucine (LKSL) at the amino terminus of LAP that is significant for LAP to interact with the KRFK sequence of TSP-1 and the modulation of latent TGF-[beta] activation by TSP1 [54].
It was easy to identify three distinct structural units in the pC9 protein sequence, which have the characteristic features of the modules of thrombospondin type I (TSP1, amino acids 45-95), low-density lipoprotein receptor domain Class A (LDLa, amino acids 100-136), and MAC/perforin domain (MACPF, amino acids 297-507) according to SMART software (http://smart.emblheidelberg.de/).
These include the cytokine transforming growth factor [beta] (TGF[beta]) [23], the matricellular proteins thrombospondin-1 (TSP1) [24], and connective tissue growth factor (CTGF) [25].
There are five known thrombospondins (TSP, also known as THBS) in vertebrates, which can be classified into two groups: the trimeric TSP1 and -2 and the pentameric TSP3, 4, and 5.
However, we found that there is no significantly different of TSP1 expression between the cancer groups and control groups.