The approved formulation of TTFC in Argentina, Australia, and Korea is DuoTrav PQ[R] (with polyquad as preservative) and in Mexico and Russia is DuoTrav BAK[R] (with benzalkonium chloride as preservative).
IOP between TTFC and beta-blocker monotherapy at week 4.
IOP at week 4 (IOP in TTFC group lower than IOP in beta-blocker group) if the true difference was >1.5 mmHg between treatments based on the assumption of a standard deviation (SD) of 3.5 mmHg and the use of a two-sample, one-sided t-test performed at a = 0.05 level of significance.
For the superiority hypothesis, TTFC treatment was considered superior to beta-blocker monotherapy if the least squares means (LSM) difference in the mean 8 a.m.
The baseline and demographic characteristics were similar between the TTFC and beta-blocker groups (Table 1).
The mean IOP ([+ or -]SD) in the TTFC and beta-blocker groups was 22.5 ([+ or -]2.5) mmHg and 22.2 ([+ or -]2.3) mmHg, respectively, at baseline.
IOP was lower in the TTFC group (16.7 [+ or -] 3.1 mmHg) than in the beta-blocker group (21.2 [+ or -] 3.1 mmHg).
IOP were greater in the TTFC group compared with the betablocker group (p < 0.0001; Figures 3(a) and 3(b)).
IOP after 4 weeks of treatment with TTFC (mean change: -3.5 [+ or -] 3.9 mmHg; percentage change: -15.3% [+ or -]16.6%).
Among patients receiving TTFC treatment for 8 weeks, the mean change in 8 a.m.
Although direct comparisons to the present study are difficult, studies involving patients with a mean pretherapy pressure of 22-24 mmHg have reported a 31-34% decrease in intraocular pressure with LTFC [15,16] and a 31-32% decrease with TTFC [17,18].
Latanoprost/LTFC Travoprost/TTFC Case number 13 14 Gender (male/female) 7/6 8/6 Age 64.0 [+ or -] 6.5 53.4 [+ or -] 7.6 Baseline IOP with GAT (mmHg) 17.6 [+ or -] 17.6 [+ or -] 1.35 1.21 Latanoprost LTFC Spherical equivalent (diopter) -4.88 [+ or -] -5.00 [+ or -] 2.5 3.2 MD score (HFA30/24-2) -3.91 [+ or -] -9.34 [+ or -] 4.13 5.0 Travoprost/TTFC Case number Gender (male/female) Age Baseline IOP with GAT 17.4 [+ or -] 17.4 [+ or -] (mmHg) 2.00 1.86 Travoprost TTFC Spherical equivalent -6.69 [+ or -] -6.89 [+ or -] (diopter) 4.07 4.03 -3.51 [+ or -] -7.12 [+ or -] MD score (HFA30/24-2) 4.27 3.24 IOP: intraocular pressure.