TTGATold to Go Away
TTGAThe Tokarz Group Advisers (Purchase, NY)
TTGATrinidad and Tobago Golf Association
TTGATaurocholate Tellurite Gelatin Agar
TTGATrans-Tasman Therapeutics Agency
References in periodicals archive ?
After treatment with sodium bisulfate, unmethylated cytosines were converted to uracils, and the TTGA and ATGT sites are not digested by these two enzymes.
Notably, cases consumed a median of 4.9 g of gluten a day before tTGA seroconversion, 1 g more than the median amount for controls of the same age (odds ratio, 1.3; 95% confidence interval, 1.1-1.5; P = .0002).
"The prospective design of this birth cohort study enabled us to obtain the diet information before seroconversion of tTGA as a marker of celiac disease," they said.
(63) These individuals are more likely to have either normal villous architecture with increased IEL counts or mild degrees of villous atrophy, and they likely lack a humoral response to the autoantigens--tissue transglutaminase or gliadin.64 The sensitivity of serum anti-EMA or tTGA antibody-based tests is low, reportedly 31% to 70% for CD with mild villous atrophy.
(93) The titers of autoantibodies for CD, including tTGA and EMA, have been shown to correlate with a greater degree of villous atrophy; hence, celiac patients with normal villous architecture are less likely to have positive celiac serologic test results.
Sensitivities and Specificities of Immunoglobulin A (IgA)-Class Antibodies Against Endomysial Antigen (EMA), Tissue Transglutaminase (tTGA), and Deamidated Gliadin Peptides (DGPs) IgA-Class Antibodies Sensitivity, % Specificity, % EMA 89-92 (55,57,58) 98-100 (55-58) tTGA 93-97 (54,55,61) 95-97 (54,56,58) DGPs 84-88 (57,61) 94-99 (57,61) Table 2.
Confirmatory testing is indicated based on the results of the initial tTGA serology.
However, the institute recommends against screening with antigliadin antibody (AGA), as this test is less sensitive and specific than tTGA or EMA.
All patients were screened with the use of serum anti-tTGA antibodies (determined by enzyme-linked immunosorbent assay 'ELISA' with human recombinant tTGA as antigen, Euroimmune[C]).
The recombinant human assay can reduce the higher FP rate obtained with guinea pig tTGA in patients with hypertransaminasemia (27).