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References in periodicals archive ?
Expression of circulating microRNA-141 and mRNA of PTEN (Phosphatase and Tensin Homolog) in blood plasma of ovarian tumor and epithelial ovarian cancer patient.
Prostat kanserinde Ras, Myc, p53 ve PTEN (phosphatase and tensin homolog deleted on chromosome ten) gibi ozel biyolojik belirtecler tanimlanmistir.
PASMC: pulmonary arterial smooth muscle cells; PAEC: pulmonary arterial endothelial cells; PTEN: phosphatase and tensin homolog deleted on chromosome 10; PDCD4: programmed cell death 4; STAT3: signal transducer and activator of transcription 3; EDN1: endothelin-1; APOE: apolipoprotein E; NO: nitric oxide; eNOS: EC nitric oxide synthase.
The top 10 DEGs with the highest degree included five upregulated DEGs such as estrogen receptor 1 (ESR1), mechanistic target of rapamycin (MTOR), ATM serine/threonine kinase (ATM), CD40 molecule (CD40) and thymidine kinase 2, mitochondrial (TK2), and five downregulated DEGs such as mitogen-activated protein kinase 14 (MAPK14), phosphatase and tensin homolog (PTEN), intercellular adhesion molecule 1 (ICAM1), aurora kinase A (AURKA), and protein kinase, DNA-activated, catalytic polypeptide (PRKDC) (Table 1).
Circulating microRNA-21 and PTEN (phosphatase and tensin homolog) are reported as promising biomarkers for detection of OSCC [17].
Increasing evidence has demonstrated that phosphatase and tensin homolog (PTEN) is closely related to renal fibrosis in DN [5,6].
Legend: mTOR: mechanistic target of rapamycin; RICTOR: rapamycin-insensitive companion of mTOR; mLST8: mammalian lethal with Sec-13 protein 8; DEPTOR: DEP domain TOR-binding protein; PROTOR: protein observed with RICTOR; mSIN1: stressactivated map kinase-interacting protein 1; PI3K: phosphatidylinositol-3-kinase; PIP2: phosphatidylinositol (4,5)-bisphosphate; PIP3: phosphatidylinositol (3,4,5)-trisphosphate; PTEN: phosphatase and tensin homolog; AKT: protein kinase B; SGK1: serum and glucocorticoid-regulated kinase 1; PKC: protein kinase C; HDACs: histone deacetylases; PFK-1: phosphofruttokinase-1; HK2: hexokinase 2; GLUT4: glucose transporter type 4; NF-[kappa]B: nuclear factor kappa-light-chain-enhancer of activated B cells.
The phosphatase and tensin homolog (PTEN) gene, at cytogenetic location 10q23.31, negatively regulates signaling pathways that are critical for cell proliferation, cell cycle progression, and apoptosis.
Additionally, phosphatase and tensin homolog on chromosome 10 (PTEN), a lipid phosphatase, converts PIP3 to PIP2, subsequently inhibiting the downstream effectors of PI3K's activation [56].
(22) have found no changes associated with resistance exercise in the PI3K/Akt cascade with subsequent activation of mTOR, despite blocking phosphatase and tensin homolog (PTEN), a negative regulator of the interaction between insulin and PI3K.