A landmark in our understanding of
testicular germ cell tumors occurred in the 1970s when, in a series of papers, Skakkebaek (2-5) convincingly demonstrated the intratubular cellular precursor to the great majority of germ cell tumors of young men.
Testicular germ cell tumors (GCTs) constitute 2% of all male malignancies and they are the most common solid malignant neoplasms in men aged 15-35 years.
Testicular germ cell tumors (TGCTs) have an incidence of up to 10.5 in 100,000 men and are the most common solid tumors affecting the young male population (1).
Moody, from King's College London, and colleagues retrospectively reviewed 103
testicular germ cell tumors (TGCTs) in men who underwent radical orchidectomy (between 2011 and 2015) in order to assess the frequency and predictors of spermatogenesis.
Clinical response of a patient to anti-PD-1 immunotherapy and the immune landscape of
testicular germ cell tumors. Cancer Immunol Res 2016;4:903-9.
Cost, "Current urologic care for
testicular germ cell tumors in pediatric and adolescent patients," Urologic Oncology: Seminars and Original Investigations, vol.
Tran et al., "Conditional survival of patients with metastatic
testicular germ cell tumors treated with first-line curative therapy," Journal of Clinical Oncology, vol.
The relative incidence of paratesticular fibrous pseudotumor in relation to
testicular germ cell tumors was reported to be 1: 200 [9].
Cryptorchidism, Klinefelter syndrome, and strong family are the predisposing risk factors in the development of
testicular germ cell tumors (GCTs).
Teratoma represents 4% of all
testicular germ cell tumors. The age of presentation is about 20-40 years.
Management of poor-prognosis
testicular germ cell tumors. Indian J Urol 2010; 26(1): 108-114.
Seminomas are primary
testicular germ cell tumors that arise from the germinal epithelium of the seminiferous tubules.