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References in periodicals archive ?
Tetrahydrofolate biosynthesis in plants; molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana.
The basic mechanism of pyrimethamine against malaria is to target on folic acid which produces tetrahydrofolates by inhibiting the enzyme dihydrofolate reductase (DHFR) (Yuvaniyama et al.
The ability of MTX to inhibit dihydrofolate reductase gives rise to reduced production of tetrahydrofolate and methyltetrahydrofolate, which are methyl donors in chemical reactions resulting in the production of methionine and S-adenosylmethionine and ultimately polyamines.
total homocysteine + thermolabile methylene tetrahydrofolate reductase (MTHFR) gene if hyperhomocysteinaemia.
There are several chemicals with folate activity, most of these being intermediates of tetrahydrofolate which is the most active form.
Methotrexate (MTX) is a folic acid antagonist which reduces the level of tetrahydrofolate in cells by inhibiting dihidrofolate reductase enzyme.
Methylene tetrahydrofolate reductase (MTHFR) and nitric oxide synthase (ecNOS) genes and risks of peripheral arterial disease and coronary heart disease: Edinburgh Artery Study.
Prevalence of methylene tetrahydrofolate reductase polymorphism in South Indian population.
Etude du Polymorphisme C677T du Gene de la Methylene Tetrahydrofolate Reductase dans la Population Tunisienne.
5) or by means of the tetrahydrofolate pathway (involving folates and vitamin B12) through methyltetrahydrofolate-homocysteine-methyltransferase (THFMT; EC 2.
The most common polymorphism involves methylene tetrahydrofolate reductase (MTHFR), an enzyme that is essential in chemical reactions involving folate.
In an experiment by Idrees et al (44) NO donors decreased [14C] methyl tetrahydrofolate incorporation into protein; and homocysteine reduced the effectiveness of PAPA-NONOate (propylamine prompylamine NONOate) as an inhibitor of de novo purine nucleotide synthesis.