biosynthesis in plants; molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana.
The basic mechanism of pyrimethamine against malaria is to target on folic acid which produces tetrahydrofolates
by inhibiting the enzyme dihydrofolate reductase (DHFR) (Yuvaniyama et al.
The ability of MTX to inhibit dihydrofolate reductase gives rise to reduced production of tetrahydrofolate
and methyltetrahydrofolate, which are methyl donors in chemical reactions resulting in the production of methionine and S-adenosylmethionine and ultimately polyamines.
total homocysteine + thermolabile methylene tetrahydrofolate
reductase (MTHFR) gene if hyperhomocysteinaemia.
There are several chemicals with folate activity, most of these being intermediates of tetrahydrofolate
which is the most active form.
Methotrexate (MTX) is a folic acid antagonist which reduces the level of tetrahydrofolate
in cells by inhibiting dihidrofolate reductase enzyme.
reductase (MTHFR) and nitric oxide synthase (ecNOS) genes and risks of peripheral arterial disease and coronary heart disease: Edinburgh Artery Study.
Prevalence of methylene tetrahydrofolate
reductase polymorphism in South Indian population.
Etude du Polymorphisme C677T du Gene de la Methylene Tetrahydrofolate
Reductase dans la Population Tunisienne.
5) or by means of the tetrahydrofolate
pathway (involving folates and vitamin B12) through methyltetrahydrofolate-homocysteine-methyltransferase (THFMT; EC 2.
The most common polymorphism involves methylene tetrahydrofolate
reductase (MTHFR), an enzyme that is essential in chemical reactions involving folate.
In an experiment by Idrees et al (44) NO donors decreased [14C] methyl tetrahydrofolate
incorporation into protein; and homocysteine reduced the effectiveness of PAPA-NONOate (propylamine prompylamine NONOate) as an inhibitor of de novo purine nucleotide synthesis.