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TexCAPSTexas Coronary Atherosclerosis Prevention Study
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Research Group: Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/ TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study.
In a second study, which was a post hoc analysis of the Primary Prevention of Acute Coronary Events with Lovastatin in Men and Women with Average Cholesterol Levels: Results of the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS / TexCAPS), lovastatin was found to be effective for the primary prevention of acute cardiovascular events in patients with chronic kidney disease, but not for reducing loss of kidney function.
Both the Heart Protection Study and the earlier Texas Coronary Atherosclerosis Prevention Study (TexCAPS) demonstrate that patients who are at high risk for atherosclerotic disease because of multiple risk factors but without prior known coronary disease can benefit from statin therapy.
(26-31) 1he Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/ TexCAPS), the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA), and the West of Scotland Coronary Prevention Study (WOSCOPS) are of particular interest because they demonstrated significant reduction in the risk of developing a first cardiac event in patients with normal to moderately high LDL-C and other CHD risk factors.