(redirected from Thiazolidinediones)
Also found in: Dictionary, Medical.
Related to Thiazolidinediones: Biguanides, meglitinides
TDZThidiazuron (plant growth induction)
TDZTouchdown Zone
TDZTechnology Development Zone (various locations)
TDZTemperature Danger Zone (food safety)
TDZThe Dead Zone (movie)
TDZTvornica Duhana Zagreb (Croatian tobacco factory)
TDZThe Directory Zone
TDZTeam Daiwa Z (fishing reel)
TDZTorpedo Danger Zone
TDZTsunami Disaster Zone
TDZTotal Danger Zone
Copyright 1988-2018, All rights reserved.
References in periodicals archive ?
(4,5) From this perspective, therapies that have a weight-neutral or weight-reducing effect (metformin, GLP-1 receptor agonists, SGLT-2 inhibitors, DPP-4 inhibitors, alpha-glucosidase inhibitors) are preferred over those that promote weight gain (sulfonylureas, insulin, thiazolidinediones).
Wahl, "Chemotherapy and chemoprevention by thiazolidinediones," BioMed Research International, vol.
As a consequence of the improvement in insulin sensitivity, PPAR[gamma] activation by thiazolidinediones decreases glycated hemoglobin (HbA1c) and lowers the glucose and insulin levels in patients with type 2 diabetes [63].
Thiazolidinediones have many adverse effects, including the risk of cardiovascular adverse events, bone fractures, bladder cancer, and hepatotoxicity.
While 2,198 patients (24.5 percent) prescribed metformin required a second oral medication, 37.1 percent of patients prescribed a sulfonylurea, 39.6 percent prescribed a thiazolidinedione and 36.2 percent prescribed a DPP-4 inhibitor did.
Thiazolidinediones (TZD): Troglitazone, one out of the three TZD, has been withdrawn worldwide because of its high hepato-toxicity (Shenfield 2001).
Thiazolidinediones could activate AMPK in adipocytes, a pathway that increases fat oxidation and glucose transport [17].
The effects of thiazolidinediones on triglycerides have been somewhat more impressive.
Thiazolidinediones contribute to adiposity and cardiovascular disease by encouraging the division and differentiation of fat cells.
Thiazolidinediones (Pioglitazone), also known as insulin sensitizers, enhances the action of insulin mainly by promoting glucose utilization in peripheral tissues and suppressing hepatic gluconeogenesis.
The newly found mitochondrial protein complex is referred to as the mitochondrial Target of Thiazolidinediones. It acts as a molecular 'sensor switch' connecting mitochondrial metabolism to important cellular activities, such as carbohydrate, lipid, and amino acid metabolism, that are out of balance in patients with type 2 diabetes.