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THPOTribal Historic Preservation Officer
THPOTris-hydroxymethylphosphine oxide
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References in periodicals archive ?
Lusutrombopag, which has already been approved for routine use in the US, EU, and Japan, is an orally active, small molecule agonist of the human thrombopoietin receptor that triggers the production of endogenous platelets.
Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis.
Relationship between thrombopoietin serum levels and liver function in patients with chronic liver disease related to hepatitis C virus infection.
Eltrombopag binds to thrombopoietin receptors and stimulates megakaryopoiesis and therefore enables platelet release from mature megakaryocytes.
Pereyra et al., "Deficiency in thrombopoietin induction after liver surgery is associated with postoperative liver dysfunction," PLoS ONE, vol.
If thrombocytopenia shows a poor response to these conventional therapies, monoclonal antibodies targeting the thrombopoietin (TPO) receptor have recently become another treatment option [1].
Standard second-line options for maintaining platelets and further inducing remission include splenectomy, rituximab, and thrombopoietin receptor agonists such as romiplostim and eltrombopag.
Varol, "Increased thrombopoietin and mean platelet volume in patients with ischemic stroke," Clinical and Applied Thrombosis/Hemostasis, vol.
In conventional expansion cultures, HSPCs are cultured in suspension cultures with various combinations of early acting cytokines, growth factors, and other growth-promoting compounds, such as stem cell factor (SCF), FMS-like tyrosine kinase 3 ligand (Flt-3L), interleukin- (IL-) 3, IL-6, thrombopoietin (TPO), erythropoietin (EPO), fibroblast growth factor 1 (FGF-1), and granulocyte colony-stimulating factor (GM-CSF) [5-7].
Lusutrombopag, which is an oral thrombopoietin receptor agonist that reduces severe thrombocytopenia in patients with chronic liver disease who are scheduled to undergo an invasive procedure, may be a useful drug in this patient.
Jelkmann, "Hepatic thrombopoietin mRNA levels in acute and chronic liver failure of childhood," Hepatology, vol.
The serum level of thrombopoietin (TPO) was also measured by ELISA (Quantikine, R&D Systems, Minneapolis, MN, USA).