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TRAF2TNF Receptor-Associated Factor 2
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References in periodicals archive ?
TRAF2: TNF receptor-associated factor 2; ASK1: apoptosis signal-regulating kinase 1; JNK: c-Jun N-terminal kinase; ATF4: activating transcription factor 4.
Levrero, "Tumor necrosis factor (TNF) receptor 1 signaling downstream of TNF receptor-associated factor 2. Nuclear factor kB (NFxB)-inducing kinase requirement for activation of activating protein 1 and NF/cB but not of c-Jun N-terminal kinase/stress-activated protein kinase, " The Journal of Biological Chemistry, vol.
Binding of the TNF-[alpha] trimer to the extracellular domain of TNFR1 induces receptor trimerization and recruitment of the adaptor protein TNF receptor-associated death domain (TRADD), which in turn recruits additional adaptor proteins: receptor-interacting protein (RIP), TNF receptor-associated factor 2 (TRAF2), and Fas-associated death domain (FADD).