The seventh article recommends, when possible, a panel of cytokeratin (CK) 7, carbonic anhydrase IX (CA IX), CD117, human melanoma black 45 (HMB-45), [alpha]-methylacyl coenzyme A racemase (AMACR), and transcription factor E3
and transcription factor EB (TFE3/TFEB) for classifying renal epithelial tumors; CK20, p53, and CD44 for bladder urothelial carcinoma versus reactive urothelium; p63, NKX 3.
2, all resulting in gene fusions involving the transcription factor E3
The majority of translocation carcinomas (90%) involve the transcription factor E3 (TFE3) located on Xp11.
Altered transcription factor E3 expression in unclassified adult renal cell carcinoma indicates adverse pathological features and poor outcome.
Alveolar soft part sarcoma is consistently positive for an antibody that detects the carboxyl terminal portion of the transcription factor E3 (TFE3) gene retained in the fusion protein.
Transcription factor E3 (TFE3) staining in alveolar soft part sarcoma.
Here, we describe an unusual mesenchymal tumor of the appendix with morphologic and immunohistochemical features of transcription factor E3 (TFE3)-positive, benign perivascular epithelioid cell tumor (PEComa) presenting as acute appendicitis.
Perivascular epithelioid cell tumor of the sigmoid colon with transcription factor E3 expression [published online ahead of print May 3, 2011].