Treg

AcronymDefinition
TregRegulatory T Cells
TregTetra-Ethylene Glycol
TregThe Real Estate Group, Inc
TregTregorrois (linguistics)
TregTelecommunications Regulatory Email Grapevine
TregRegolith Temperature
TregTunnel Research & Exploration Group (UK)
References in periodicals archive ?
This entails decreasing Th17 and Th2 while increasing Th1 and Treg cells.
Quell has been established with the aim of developing engineered T regulatory cell, or Tregs, therapies.
Researchers engineered the TCRm antibody in both bispecific T-cell engager and full-length antibody formats and demonstrated that the TCRm antibody induces peptide-specific killing activities against Foxp3+ human Treg in both in vitro and in vivo settings.
Th17/ Treg dysregulation in allergic asthmatic children is associated with elevated notch expression.
Observation of CD4+ RORg-T Th17 and CD25+ FOXP3 Treg were conducted with immunohistochemistry staining technique using anti FOX-P3 and anti RORg-T.
Thonhoff, M.D., Ph.D., from the Houston Methodist Neurological Institute, and colleagues assessed the safety and tolerability of autologous infusions of expanded regulatory T lymphocytes (Tregs) in three patients with ALS but no family history.
The company's two lead programmes, an immunomodulatory anti-CD38 antibody directed against a novel epitope of the CD38 protein and an anti-CD25 Treg depleting antibody, are in both in pre-clinical development.
While the exact causes of autoimmune disease remain unclear, scientists know that these diseases, ranging from MS to asthma, have something in common--the failure of helper T-cells to develop into regulatory T-cells, also known as Tregs. Tregs ameliorate inflammation and stop the immune system from attacking the body's own tissues.
In order to investigate whether T cell polarization is influenced by RC, we evaluated the expression of the transcription factors T-box expressed in T cells (T-bet) for Th1, GATA binding protein 3 (GATA 3) for Th2, RAR-related orphan receptor gamma T (ROR[gamma]T) for Th17 and forkhead box P3 (Foxp3) for Treg cells in the MLN and spleen.
It has been reported that Notch signaling may play a decisive role in the differentiation of T cells into the initial stage of Th17 and/or Treg cells [18], and some studies have also indicated the role of Notch signaling in the regulation of Th17 cell differentiation and function as well as its recovery effect on Th17/ Treg immune imbalance in some autoimmune and inflammatory diseases [19-23].
reported that while Treg frequencies remained unchanged, there was a marked decrease in their potential to suppress the effector Th17 cells in a mouse model of DED.
Most of the conducted studies link increased Treg frequencies with an unfavorable MDS prognosis [4-7].