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TRKATyrosine Receptor Kinase A (biochemistry)
TRKATropomyosin-Receptor Kinase A
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Tissue sections (3 [micro]m) were prepared from surgical samples and immunostained using the Power Vision Two-Step Kit (ZSG, Beijing, China) according to the manufacturer's instructions, with primary rabbit polyclonal antibodies (Hengxin Biotech, Nanning, China) against NGF (1:200), TrkA (1:200), and p75NRT (1:150).
Chao, "Ginsenoside Rb1 regulates ChAT, NGF and trkA mRNA expression in the rat brain," Molecular Brain Research, vol.
Specifically, downregulation of c-kit increased the expression of the neurotrophin TrkA receptor, which is a prerequisite for spontaneous regression of neuroblastoma, and also increased expression of HLA class I genes and levels of IFNGR expression, which significantly raises the sensitivity of tumor cells towards the components of the immune system [96].
The release of NGF can further bind the TrkA receptor and activate the PI3 kinase and Src kinase to phosphorylate TRPV1 [30].
(27.) Lenfeld J, Motl O, Trka A, Anti-inflammatory activity of extracts from Conyza canadensis, Pharmazie 41, 268-269, 1986.
It turns out that a different protein, TrkA, is the key to the missing pain signals, Gary Lewin of the Max Delbruck Center for Molecular Medicine in Berlin and colleagues report in the Oct.
A study of the toxic effect of oxidized sunflower oil containing 4- hydroperoxy2-nonenal and 4-hydroxy-2-nonenal on cortical TrkA receptor expression in rats.
(37) In addition, a previous report indicated that dysfunction of BDNF and NGF, as well as of their respective receptors tropomyosin receptor kinase B (TrkB) and tropomyosin receptor kinase A (TrkA), could contribute to the pathogenesis of both depression and obesity.
Among de molecular characteristics of PTC, there are those related to changes in chromosomal rearrangements such as RTK, RET and TRKA, and those related to mutational changes like BRAS, RAS, PI3K, PTEN, IDH1 and p53 [57-63].