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TRKBTropomyosin-Related Kinase B
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In our study, we observed no significant correlation between the expression of TRKB and the expression of other selected genes in the BDNF signaling pathway.
Abnormality in the way BDNF communicates with the receptor TrkB leads to impaired poor cardiac function.
1) on BDNF/TrkB/ERK and BDNF/TrkB/PI3K signaling pathways by using TrkB, ERK and PI3K antagonists to specifically antagonize various signaling pathways, and Western blot assay was used to evaluate the changes of neurotrophic factor BDNF and key proteins expression in various pathways before and after antagonizing to further reveal its molecular mechanism in neuro-protective effect.
2008) Upregulation of hippocampal TrkB and synaptotagmin is involved in treadmill exercise-enhanced aversive memory in mice.
The genetically altered mice were unique in that a drug, 1NMPP1, inhibited TrkB in their brains.
Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments.
McNamara and his team put this theory to the test by introducing a TrkB inhibitor to genetically engineered mice soon after they had experienced an episode of status epilepticus.
Correlations among neural cell adhesion molecule, nerve growth factor, and its receptors, TrkA, TrkB, TrkC, and p75, in perineural invasion by basal cell and cutaneous squamous cell carcinomas.
6 The Selective TrkB Agonist, 7, 8-Dihydroxyflavone, Enhances Motor Performance and Promotes Motor Map Integrity Following Cortical Stroke
The hyperexcitability develops after BDNF administration in combined entorhinal/hippocampal slices of rat brains, and this effect may be due to a presynaptic action on trkB receptor (Scharfman, 1997).
A possible mechanism for this excessive reduction of serum BDNF in the active group is an enhanced utilization mediated by the upregulation of BDNF TrkB (tyrosine protein kinase) receptor in the peripheral tissues.