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TrkA for NGF, TrkB for BDNF and NT4, and TrkC for NT3) and p75 receptors.
In the study, NT-3 was found to be expressed at increased levels in aggressive human neuroblastomas and to block the ability of TrkC to induce tumour cell death by a process known as apoptosis.
Voluntary exercise increases neurotrophin-3 and its receptor TrkC in the spinal cord.
The presence of neurotrophins and the neurotrophin receptors p75 (p75NTR), tyrosine kinase A (TrkA), TrkB and TrkC are present in several immune cells.
Relatives of trk are receptors for other neurotrophic factors--trkB seems to be a receptor for brain-derived neurotrophic factor, and trkC for neurotrophin-3.
Thus the trkA-expressing PC12 cells and chromaffin cells are in good contrast with central neurons expressing trkB or trkC corresponding to BDNF or NT-3 (see |9, 10~ for reviews).
Fusion of ETV6 to neurotrophin-3 receptor TRKC in acute myeloid leukemia with t(12;15)(p13;q25).
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- TrizecHahn Office Properties
- TriZenter Presentation System
- TRK E
- TRK UP
- TRK1-transforming tyrosine kinase protein
- TrkB tyrosine kinase
- TrkC tyrosine kinase