Three patients (1.4%) presented to us with type 1 reaction
and 21 patients (9.5%) presented with type 2 reaction at the first visit.
Overall, our results provide some evidence to the hypothesis that, in type 1 reaction
, downmodulation of Tregs would favor the development of Th-17 responses that characterize this type of reaction.
Out of 50 patients who fulfilled the inclusion criteria 70% of the patients were found to be having type 2 reaction while 30% patients had type 1 reaction
Five patients presented with Type 1 reaction
and three with Type 2 reactions; 37.5% of nerves (six of 16) with clinical evidence of reaction showed endoneural vascularity as compared to 12.5% of nerves in patients without reaction (10 of 80).
Among type 1 reaction
, 4 cases were BB, 2 BL and 1 BT patient.
13 (19%) patients showed features of type 1 reaction
while none had type 2 reactions.
In the English literature, there are only few reports of Type 2 reaction and a case report of de novo HL developing Type 1 reaction
after 10 weeks of multibacillary multi-drug therapy.
Nerve abscesses in the upper pole of leprosy are associated with an upgrading Type 1 reaction
and demonstration of AFB is uncommon.
Type 1 reaction
was more common in BT patients (50%), whereas type 2 reaction were more commonly seen in LL patients (32%).
Firstly, the course of the disease is too rapid for leprosy--even if a Type 1 reaction
Type 1 reaction
(T1R) in leprosy is common and characterized by increased inflammation in skin lesions or nerve.
leprae play an important role in the precipitation of Type 1 reaction