ROS-1 is a proto-oncogene that is located on chromosome 6 that encodes the transmembrane tyrosine kinase receptors
of the insulin receptor family.
Molina-Pinelo, "Tyrosine kinase receptor
landscape in lung cancer: therapeutical implications," Disease Markers, vol.
HER2 is a transmembrane tyrosine kinase receptor
protein with 185-KD.
Grb10 seems to be involved in these two processes through interaction with tyrosine kinase receptors
. In mouse embryonic fibroblast cell lines, IGF-I-mediated mitosis is inhibited by Grb10 (MORRIONE et al., 1997).
The growth factor SVH-1 and its tyrosine kinase receptor
SVH-2 regulate axon regeneration via the JNK MAPK pathway
These anti-VEGF therapies consist of VEGF-neutralizing antibodies and tyrosine kinase receptor
The location of the mutation in the activation loop of the KIT tyrosine kinase receptor
precludes use of the tyrosine kinase inhibitor imatinib.
Members of the epidermal growth factor receptor (EGFR) family are transmembrane tyrosine kinase receptors
that, with the exception of HER2, are activated by extracellular ligands belonging to the epidermal growth factor family (Figure 1).
(6,7) These agents target the intracellular domain of the tyrosine kinase receptor
within the cytoplasm of the target cell and compete with ATP to bind on the kinase domain.
(21) For instance, the ECD deletion-activated Ret receptor, another trans-membrane tyrosine kinase receptor
, is the cause of multiple endocrine neoplasia (MEN) syndrome, as well a form of thyroid cancer.
A novel putative tyrosine kinase receptor
encoded by the eph gene.
reviewed tyrosine kinase receptor
with its therapeutical implications in lung cancer showing that in the "omics" landscape tyrosine kinase receptors
gained their role in the different histological types of lung cancer.