ROS-1 is a proto-oncogene that is located on chromosome 6 that encodes the transmembrane
tyrosine kinase receptors of the insulin receptor family.
Molina-Pinelo, "
Tyrosine kinase receptor landscape in lung cancer: therapeutical implications," Disease Markers, vol.
HER2 is a transmembrane
tyrosine kinase receptor protein with 185-KD.
Grb10 seems to be involved in these two processes through interaction with
tyrosine kinase receptors. In mouse embryonic fibroblast cell lines, IGF-I-mediated mitosis is inhibited by Grb10 (MORRIONE et al., 1997).
The growth factor SVH-1 and its
tyrosine kinase receptor SVH-2 regulate axon regeneration via the JNK MAPK pathway
These anti-VEGF therapies consist of VEGF-neutralizing antibodies and
tyrosine kinase receptor inhibitors.
The location of the mutation in the activation loop of the KIT
tyrosine kinase receptor precludes use of the tyrosine kinase inhibitor imatinib.
Members of the epidermal growth factor receptor (EGFR) family are transmembrane
tyrosine kinase receptors that, with the exception of HER2, are activated by extracellular ligands belonging to the epidermal growth factor family (Figure 1).
(6,7) These agents target the intracellular domain of the
tyrosine kinase receptor within the cytoplasm of the target cell and compete with ATP to bind on the kinase domain.
(21) For instance, the ECD deletion-activated Ret receptor, another trans-membrane
tyrosine kinase receptor, is the cause of multiple endocrine neoplasia (MEN) syndrome, as well a form of thyroid cancer.
A novel putative
tyrosine kinase receptor encoded by the eph gene.
reviewed
tyrosine kinase receptor with its therapeutical implications in lung cancer showing that in the "omics" landscape
tyrosine kinase receptors gained their role in the different histological types of lung cancer.
