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Related to Tyrosine hydroxylase: DOPA decarboxylase
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References in periodicals archive ?
Caption: Figure 3: Immunofluorescence of unsorted H9 hESCs on day 21 of neuronal differentiation demonstrating expression of (a) neural cell adhesion molecule (NCAM), (b) tyrosine hydroxylase (TH), (c) peripherin (PRPH), and (d) dopamine betahydroxylase (DBH).
Shakil et al., "A synopsis on the role of tyrosine hydroxylase in Parkinson's disease," CNS & Neurological Disorders Drug Targets, vol.
Consequently, we could infer that this characteristic is responsible for the delay in the onset of motor deficits in the catalepsy test, as well as the decrease in tyrosine hydroxylase depletion in SNpc cells.
Lastly, intrathyroid parathyroid proliferations are immunoreactive with AE1/AE3, parathyroid hormone, and chromogranin and are negative for tyrosine hydroxylase, thyroglobulin, and calcitonin.
Immunohistochemistry for Tyrosine Hydroxylase. The tyrosine hydroxylase enzyme (TH) is the rate-limiting step for dopamine synthesis.
Structure of the human tyrosine hydroxylase gene: alternative splicing from a single gene accounts for generation of four mRNA types.
Kang, "Double transduction with GTP cyclohydrolase I and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblasts," Journal of Neuroscience, vol.
Tyrosine hydroxylase (TH), which initiates dopamine synthesis, is abundant in periglomerular (PG) cells in the MOB, and its expression is a useful marker for monitoring olfactory function [18,19].
Scientists believe it does this by secreting an enzyme called tyrosine hydroxylase, which catalyzes the formation of dopamine, a neurotransmitter integral to reward and pleasure pathways in the brain.
Of special interest to the researchers were: 1) the mice's locomotor activity in response to cocaine; 2) the degree of conditioning for place preference; 3) electrical activity of the ventral tegmental area (part of the brain's reward system; it plays a role in sense of euphoria and well-being); 4) the presence of tyrosine hydroxylase in the VTA; and 5) the presence of deoxyribonucleic acid (DNA) sequences for the Clock gene in the brain.
Cannabinoids were without effect on the morphology of dopaminergic cells stained by tyrosine hydroxylase (TH) immunoreaction.
Increased tyrosine hydroxylase activity was found on both the RLS autopsy and the rodent iron-deprivation model of RLS, suggesting increased DA synthesis in RLS.