U937human myelomonocytic leukemia cells
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Effect of vitamin B6 on oxygen radicals, mitochondrial membrane potential, and lipid peroxidation in H202-treated U937 monocytes.
In addition, a cardiotonic steroid, bufalin, has been shown to induce differentiation of human myeloid leukemia-derived cell lines, HL-60, U937 and ML1, and leukemic cells from 4 of 20 AML patients in primary culture [39,40].
Retinoid receptor binding sites have been identified in the promoter region for MMP-21 expression, thus retinoic acid upregulates MMP21 mRNA in monocytic U937 cells [1] and the enzyme has been found in cancer cells.
Microarray analysis of 15,067 known human genes and ESTs was used to identify altered gene transcription in U937 cells following incubation with Sol B (13 mM) for 1 or 6 hours.
The combination of apoptotic U937 cells and lupus IgG is a potent IFN-alpha inducer.
Cellular studies have revealed that combinations of vitamin D derivatives and retinoids, such as ATRA and 9-cis-RA, exhibit positive effects on differentiation in established leukemia cell lines such as HL-60, U937, and NB4 (James et al.
Also, the present invention relates to a process for producing the endonuclease which comprises culturing human B-lymphoblastic IM9 cell line or TPA-treated myelogenous U937 cell line on an appropriate medium to produce the said endonuclease and isolating the said endonuclease from the cell lysate or the culture medium.
Untreated and control cells were cultured side by side with U937 cells treated with various concentrations (0-180 M) of 4,4'-bipyridin-1-ium bromide monohydrate.
The paper, entitled "IL-8 and MCP-1 Secretion is Enhanced by the Peptide-Nucleic Acid Immunomodulator, Product R, in U937 Cells and Primary Human Monocytes", was based on work done by the Company's Immunology Group, and was published in the scientific journal Cytokine (Volume 14, Number 4, pages 234-239).
Attempts were made to culture sarcocysts from muscle tissue homogenates in U937 and THP-1 human monocytic cell lines but no propagation of bradyzoites was obtained.
Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937.