UCHMUnited Crescent Hill Ministries (Louisville, KY)
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The body weights of rats in the UCHM group increased on days 11-12 (P < 0.05) and significantly increased on days 13-14 (P < 0.001) compared to the UC group rats (Figure 3).
In the UCHM group, the adhesion was attenuated compared to the UC group, and the bleeding points were decreased, the inner wall was not smooth, and a small amount of or no residual blood and loose stool were observed (Figures 4(a)-4(c)).
In the UCHM group, ulcer healing and epithelial hyperplasia covering the mucosa on the surface of the ulcer were observed; additionally, the morphology of the peripheral glands was irregular, the mucosa and submucosa had mild congestion and edema, and there was a small amount of lymphocyte and plasma cell infiltration (Figures 4(d)-4(f)).
There were 15 differentially expressed miRNAs in the colon tissues of the UCHM group compared to the UC group, of which 13 were upregulated and 2 were downregulated.
The miR-184 expression level increased and the miR-490-5p expression level decreased in the UCHM group compared to the UC group (both P < 0.05) (Figures 9(a) and 9(b)).
The increase in body weight was slow, with the body weights on day 14 significantly different from the body weights in the NC and UCHM groups.
The results in this study suggested that changes in miR-184 and miR-490-5p expression levels in colon tissues under the UC pathological status were reversed in the UCHM group.
Compared to the UC group, the body weights of rats in the UCHM group increased ((#) P < 0.05, (##) P < 0.001).
NC, normal group; UC, UC group; UCHM, herb-partitioned moxibustion group (each group, n = 10).
Caption: Figure 7: The differentially expressed miRNA profile of UCHM versus UC.