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As the miR-30e/UCP2 axis plays significant roles in the course of mitochondria dysfunction or damage and renal fibrosis, thus UCP2 blockers could be used in this pathway to be new therapies for renal fibrosis.
These subjects completed the first examination of NILS-LSA between November 1997 and April 2000, and the analyses of UCP2 rs660339 gene were sampled.
Regulation of UCP1, UCP2, and UCP3 mRNA expression in brown adipose tissue, white adipose tissue, and skeletal muscle in rats by estrogen.
The uncoupling mechanism of ANT, along with UCP2 and UCP3, may be the exchange of protonated fatty acids from the mitochondrial intermembrane space for fatty acid anions in the matrix, thereby dissipating Ap [123, 137-139].
Peroxisome proliferator-activated receptor (PPARs) play pivotal roles in the control of the transcription of UCP2 [11, 12].
Esteves, "Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3," Cell Metabolism, vol.
UCP2, an inner mitochondrial carrier protein which encoded by the UCP2 gene, is widely expressed in tissues, including pancreatic islets (89,90).
Bu calismanin sonucunda, beyaz yag dokusu ve iskelet kas dokusunda UCP2 gen ekspresyonun arttigi, kahverengi yag dokusunda ise UCP1 gen ekspresyonun arttigi rapor edilmis ve borik asidin bu sayede termogenezi arttirip, vucut agirliginda azalmayi saglayabilecegi bildirilmistir (31).
The levels of estrogen receptor alpha (ESR1) and uncoupling protein 2 (UCP2) proteins were measured in lysates by using mouse ESR1 (Aviva Systems Biology), and mouse UCP2-Ab (MyBioSource) ELISA kits, following the manufacturer's instructions.
Parton et al., "Glucose stimulation of hypothalamic MCH neurons involves KATP channels, is modulated by ucp2, and regulates peripheral glucose homeostasis," Cell Metabolism, vol.
Increased fatty acid oxidation leads to the generation of reactive oxygen species (ROS) and consequently stimulates uncoupling protein 2 (UCP2) .
In a similar manner, the Ala55Val polymorphism (rs660339) of UCP2 gene was associated with severe forms of obesity in a Han Chinese population .
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