A WBC count of 100 X [10.sup.3]/gL or higher and an LDH level 2 times the ULN
or higher generally place patients in higher-risk groups.
Furthermore, in both the Chinese subpopulation and overall TOWER population, ALT elevations >2 x ULN
and >3 x ULN
were more common with teriflunomide 14 mg than in the placebo group.
By contrast, the APASL and EASL guidelines acknowledge the lack of available data to support the need for decreasing the traditional thresholds for the ULN
of ALT values.
Once the patient was found to be suffering from liver damage due to the use of antipsychotic drugs (ALT[greater than or equal to] 3 times ULN
or ALP[greater than or equal to] 2 times ULN
or TB> 2mg/dl), it is suggested to stop the medication treatment as soon as possible, receive liver-protecting treatment, or get a referral to a general hospital.
Determinants of significant liver fibrosis in chronic hepatitis B patients for multivariable logistic regression analysis were gender (reference, female gender), BMI, comorbidity of diabetes mellitus, AST (reference, ULN
and unit of AST independent variable, n-foldULN), ALT (reference, ULN
and unit of ALT independent variable, n-fold ULN
), ALP (U/L), and hemoglobin (g/dL).
(2) Patients with virologic relapse would go on for the next visit if ALT [less than or equal to] 2 times ULN
. (3) Patients with clinical relapse would go on for the next visit if they have no symptoms and ALT [less than or equal to] 5 times ULN
Few studies have been conducted to develop or evaluate noninvasive approaches in identifying liver fibrosis in hepatitis B e-antigen- (HBeAg-) positive chronic hepatitis B patients with normal or minimally elevated ALT levels (usually ALT of <2 upper limit of normal value (ULN
On admission to the ICU, his labs were as follows: sodium 130 mEq/L (upper limit of normal (ULN
) 135 mEq/L), potassium 5.6 mEq/L (ULN
5 mEq/L), creatinine 1.5 mg/dl (ULN
1.3 mg/dl), AST 3534 U/L (ULN
39U/L), ALT 3206 U/L (ULN
52U/L), total bilirubin within normal limits, INR 1.7, and WBC 21.9 (ULN
More than one year after starting sirolimus, patient's liver function tests are nearly left intact (last test results: ALT 45 U/L, aspartate aminotransferase (AST) 34 U/L (ULN
for women 31 U/L), alkaline phosphatase 309 U/L (ULN
for women <306 U/L), total bilirubin 1.02mg/dl, urea 34mg/dl, creatinine 0.83 mg/dl).
In hepatocellular injury, the ALT is usually >three times the upper limit of normal (ULN
), alkaline phosphatase is more than two times the ULN
, or total bilirubin is more than twice the ULN
To normalize IGF-1 for age in individual patients, we calculated the ratio between the IGF-1 level and the upper limit of the normal (ULN
) range for age (normal [less than or equal to] 1) and the data are presented as IGF-1 ULN
The ESMO statement refers to grade 3 ALT/AST elevation as 5-20x the upper limit of normal (ULN
) and grade 4 elevation as >20x the ULN
, whereas our algorithm and eviQ specify grade 3-4 AST/ALT elevation as >5x the ULN