The variables that differed significantly between patients with high and low uNCR were used as predictor variables in multiple regression analysis.
Also, the average concentrations of urine albumin and NGAL, as well as the values of uACR and uNCR, did not differ between diabetic patients and control subjects (Table 1).
T2DM patients with uNCR above the maximum control value were characterized by higher triglycerides, total cholesterol, and LDL-cholesterol, as well as higher urine albumin and uACR as compared to patients with lower uNCR (Table 2).
Among 123 T2DM patients, 94 (76%) underwent the ophthalmologic examination, including 83 with low uNCR and 11 with high uNCR.
In control group, no significant correlation was observed between uNCR and uACR.
Special attention was paid to the changes in uNGAL concentrations and uNCR values after treatment.
Multiple logistic regression was calculated to study the association between cardiovascular complications and uACR and uNCR values, with adjustment for classical cardiovascular risk factors.
Patients with cardiovascular complications were characterized with older age, higher albuminuria and uACR values, and higher uNCR values (Table 1).
In turn, uNCR increased in 9 patients (30%) and decreased in 21 (70%).
The change in eGFR was negatively correlated with the initial values of uNCR (R = -0.38; p = 0.036) and the control concentration of uNGAL (R = -0.51; p = 0.004).
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7630 1078 2262 08; bic uncrbgsf.