UPJSUniverzita Pavol Jozef Safarika
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Sunday 31 August 2014 UPJS Rectorate and Campus, Srobdrova 2
Monday 1 September 2014 UPJS Rectorate and Campus, Srobdrova 2
Tuesday 2 September 2014 UPJS Rectorate and Campus, Srobdrova 2
The renal calyces, renal pelvis, UPJ, ureters (proximal to distal), ureteral orifices, fundus and corpus of the bladder in porcines were evaluated by Metzger and colleagues.[sup.8] c-kit expression was examined at the level of mRNA in ureteral tissue and the highest expression of c-kit mRNA was determined to be in the UPJ.[sup.9] Similarly, the authors studied ICC in the human upper urinary system and 56 ureters were examined.
We investigate the quantitative and ultrastructural changes of ICC UPJ obstruction using light and electron microscopy.
Of this total number, 42 patients were examined by immunohistochemical methods: 35 patients with UPJ obstruction (median age 36 months) and 7 patients without obstruction (median age 348 months).
Tissues, 2 cm in length and including the UPJ, were obtained from the cases with obstruction.
Specimens from 7 patients with UPJ obstruction (median 9 months) and 3 patients without obstruction (median 600 months) were examined with an electron microscope (Table 2).
The ratio of areas with no cells in the UPJ obstruction group was significantly higher when compared to the control group.
The cell count in the group with UPJ obstruction was sparse in 8 patients (22.9%), few in 26 patients (74.3%) and many in 1 patient (2.9%).
c-kit positive Cajal cells, which are easily distinguished from the mast cells in the UPJ, were demonstrated in this study.
The pathophysiology of congenital UPJ obstruction is controversial.