UPSITUniversity of Pennsylvania Smell Identification Test
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His study concluded that the UPSIT predicted Alzheimer's disease almost as well as invasive amyloid biomarkers.
The UPSIT Series, which objectively measures smell identification ability, makes it possible to detect and track changes in physical condition and psychological state.
Kreisl examined the relationship between UPSIT and brain amyloid beta in 84 subjects, 58 of whom had mild cognitive impairment (MCI) at baseline.
A linear regression model evaluated associations between the UPSIT and amyloid burden, hippocampal size, and thinning of the entorhinal cortex.
According to the findings, in 757 participants who were followed, lower odour identification scores on UPSIT were notably related to the transition to dementia and Alzheimer's disease, after controlling for demographic, cognitive and functional measures, language of administration and apolipoprotein E genotype.
The UPSIT scores used for analysis were the number of correctly identified odors (from a possible 12).
The stimuli consisted of 10 microencapsulated odors from the UPSIT not used in the multiple-choice version.
The primary outcome was the change in UPSIT scores from (1) baseline to EOT and (2) baseline to EOT+4.
Stern and his colleagues at the University of Pennsylvania and elsewhere have begun investigating tools such as UPSIT for early screening.
The sensitivity and specificity of UPSIT screening alone and combined UPSIT/DAT screening were determined by comparison to a clinical follow-up examination at 6 months and 12 months.