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USP1Ubiquitin Specific Protease 1 (gene)
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"The USP1 is a headphone that I am extremely proud of and we worked a long time to find the right sources for the materials," says Aaron Fournier, President and CEO of THINKSOUND.
To prevent its overactivation, RIG-I is actively targeted by many cellular factors that inhibit K63 ubiquitination (CYLD, USP1, and USP3) or tag it for proteasome degradation via K48 ubiquitin linkage (RNF122, RNF125) [19-23].
It has been shown that USP1 contains three candidate NLSs and those three AA regions display different degrees of nuclear import activity, but USP1 nuclear localization requires any two of the three (13).