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USPIO-MRI represents marking the macrophages (specific inflammatory cells in nephropathy) using USPIO particles (ultra-small paramagnetic iron oxide particles).
Changes in iron concentration following USPIO injection can be further quantified from these pixel distributions according to parametric relations between these observables and known iron standards, iron-labeled cells, or biopsy iron measurement to provide quantitative estimates on nanoparticle delivery, cellular uptake, and concentration [13-16].
Literaturde son zamanlarda SPIO veya USPIO ile intravenoz ve interstisyel MR lenfografi ile ilgili calismalar yapilmaktadir.
Recently, EVs were labeled with USPIOs, which shows decreased signal intensity in T2-weighted images [19, 43].
Oghabian, "Effect of functional group and surface charge of PEG and dextran-coated USPIO as a contrast agent in MRI on relaxivity constant," Applied Magnetic Resonance, vol.
Polycation TAs are macromolecular substances with positively charged surfaces that may include polylysine20 or protamine sulfate.18 With a strong positive/negative interaction SPIO/TA composites are able to adhere to the surface of cell membranes improve the phagocytosis of iron oxide particles and avoid aggregation of SPIO particles.21 For example Frank and colleagues mixed Ferumoxides (Feridex) with USPIO (MION-46 L) and added cationic TAs successfully raising the concentration of intracellular SPIO particles.
USPIO was detected with the Prussian blue iron staining method.
Several groups have evaluated the use of ultrasmall, superparamagnetic iron oxide (USPIO) enhancement of MRI in preoperative lymph node staging (known as MR lymphangiography) [25-28], Iron oxide particles are taken up by normal lymph nodes, but not by tumour cells.
The team of researchers from Belgium and Spain tested USPIO (ultra small superparamagnetic iron oxide) contrast agents (Resovist, Endorem and Sinerem) on mouse embryonic stem cells (mESC), rat multipotent adult progenitor cells (rMAPC) and mouse mesenchymal stem cells (mMSC).
The team of researchers from Belgium and Spain tested USPIO (ultra small super-paramagnetic iron oxide) contrast agents (Resovist, Endorem and Sinerem) on mouse embryonic stem cells (mESC), rat multipotent adult progenitor cells (rMAPC) and mouse mensenchymal stem cells (mMSC).
T1 and T2 relaxivity of intracellular and extracellular USPIO at 1.5T and 3T clinical MR scanning.
In a study by Neumaier et al., tumor bearing mice were injected with human natural killer T cells labeled with an USPIO. A 35% increase in transverse relaxation time was achieved in in vivo MR images of human breast cancer cells at 1.5 T.
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- Uspenskii, Evgenii
- Uspenskii, Evgenii Evgenevich
- Uspenskii, Fedor
- Uspenskii, Fedor Ivanovich
- Uspenskii, Gleb
- Uspenskii, Gleb Ivanovich
- Uspenskii, Konstantin
- Uspenskii, Konstantin Nikolaevich
- Uspenskii, Lev
- Uspenskii, Lev Vasilevich
- Uspenskii, Nikolai
- Uspenskii, Nikolai Vasilevich
- Uspenskii, Viktor
- Uspenskii, Viktor Aleksandrovich