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UCP2Uncoupling Protein 2
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AmicroRNA-30e/mitochondrial uncoupling protein 2 axis mediates TGF-[sz]1-induced tubular epithelial cell extracellular matrix production and kidney fibrosis.
Genotype distribution in SD cases and controls Controls SD patients Total n=2048 Total n=83 Genotype n (%) n (%) (vs controls) p UCP2 (rs660339) CC 549 (26.81) 15 (18.07) 0.1571 CT 1032 (50.39) 44 (53.01) TT 467 (22.80) 24 (28.92) SD: sudden deafness; UCP2: uncoupling protein 2 Table 4.
Hu et al., "Uncoupling protein 2 increases susceptibility to lipopolysaccharide-induced acute lung injury in mice," Mediators of Inflammation, vol.
Wheeler, "Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets," Diabetes, vol.
Zou, "Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2," PLoS ONE, vol.
Yang et al., "Uncoupling protein 2 ablation exacerbates high-salt intake-induced vascular dysfunction," American Journal of Hypertension, vol.
Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet.
EBR treatment induced the expression in white adipocytes of lipolysis-related genes, including beta(3)-adrenergic receptor (beta(3)-AR), hormone-sensitive lipase (HSL), adipose triglyceride lipase, and uncoupling protein 2. Furthermore, the activation of cyclic AMP-dependent protein kinase, HSL, and extracellular signal-regulated kinase was induced in EBR-treated 3T3-L1 cells.
To do so, they created a mouse model that produced large quantities of uncoupling protein 2 in hypocretin neurons in the lateral hypothalamus, which is near the preoptic area.
Studies have indicated that a subo stance called uncoupling protein 2 (UCP2), which is also secreted by pancreatic cells, reduces how much insulin is produced.
Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans.