Sabourin et al., "Myotonic dystrophy mutation: an unstable CTG repeat in the 3; untranslated region
of the gene," Science, vol.
HLA-G expression is also controlled at the posttranscriptional levels by mechanisms targeting the 31 untranslated region
(37 UTR) that affect mRNA stability [78, 81] and by specific microRNAs (miR-133a, miR-148a, miR-148b, and miR-152) [82, 83].
Sy's novel study on genetics-based drug dosage is entitled, "Single nucleotide polymorphisms in the 3' untranslated region
of the pregnane X receptor gene and inter-individual variability in drug responses."
The single-stranded RNA genome is composed of 8,026 nucleotides containing 2 large open reading frames (ORFs) in the sense orientation with an untranslated region
(UTR) at each end and between the two ORFs.
The KRAS oncogene produces a protein involved primarily in regulating cell division.The defect found in the women with endometriosis has been localized to a regulatory region of the KRAS gene: the let-7 microRNA (miRNA) binding site in the three prime untranslated region
It has a single-stranded, positive RNA genome of 7.3 kb in length and contains 5' untranslated region
(UTR), three open reading frames (ORF 1, 2 and 3) encoding a non-structural protein, a capsid protein and a non structural phosphoprotein, respectively and 3' UTR.
For example, +405 G>C polymorphism in 5' untranslated region
affects the level of VEGF protein expression (16, 17).
Evolutionary conservation of the AU-rich untranslated region
of messenger RNA.
One of the primary genetic determinants in atopic dermatitis appears to be a change in the 3' untranslated region
of the stratum corneum chymotryptic enzyme (SCCE) gene, which regulates protease activity
The molecular defect underlying DM is the expansion of an unstable [(CTG).sub.n] trinucleotide repeat in the 3' untranslated region
of a protein kinase gene, DMPK, on chromosome 19q13.3 (Buxton et al.
Similarly, a microarray element may lack specificity because it corresponds to a sequence (e.g., a 3' untranslated region
) common to several alternatively spliced transcripts, for example, the UDP-glucuronyltransferase 1A family, where seven transcripts (UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, and UGT1A9) all share the same 3' sequences (Burchell et al.
One of them is located within the 5' untranslated region
and is 597 bp in length.