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ULT should be initiated to treat to a target serum urate level of <360 [micro]mol/L in patients with renal impairment (GFR categories ≥G2) or HUA patients (SUA >480 [micro]mol/L) with uric acid nephrolithiasis. In patients with severe gout (such as tophi, chronic arthritis, and frequent attacks), the serum urate level should be controlled more strictly with a target value <300 [micro]mol/L but lowering the level to <180 [micro]mol/L is not recommended.[37],[50],[51]
Sakhaee, "The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistance," Kidney International, vol.
Uric acid nephrolithiasis. Urol Clin North Am 2007; 34:335-46.