Vesicle-associated membrane protein-associated protein A (VAPA
) presents in the plasma membrane and intracellular vesicles.
Corresponding Author: Dr Dusan Vapa
, Medicinski fakultet Novi Sad, Zavod za sudsku medicinu, 21000 Novi Sad, Hajduk Veljkova 3, E-mail: firstname.lastname@example.org
Mucosal co-immunization of mice with recombinant lactococci secreting VapA
antigen and leptin elicits a protective immune response against Rhodococcus equi infection.
Hondalus, "Deletion of vapA
encoding Virulence Associated Protein A attenuates the intracellular actinomycete Rhodococcus equi " Molecular Microbiology, vol.
equi vaccine candidate containing a water-based nanoparticle mineral oil adjuvanted (IMS 3012, SEPPIC, Paris, France) inactive antigen and VapA
. Four mares not vaccinated formed the control group.
The Keck School investigators found that interferon-inducible transmembrane protein 3 (IFITM3) can disrupt the interaction between Vesicle-membrane-associated protein (VAPA
) and oxysterol-binding protein (OSBP) that regulates the transport and stability of cholesterol, which are required for many viruses to take hold.
Analysis of BLAST results revealed that in forward library, as shown in Table 2, 30 sequences have high degree of similarity with known or predicted genes in GenBank, such as P21 protein (Cdc42/Rac)-activated kinase 2, transcript variant 2 (PAK2), Stathmin-2 (STMN2), Synaptotagmin-1(SYT1), Sprouty-related, EVH1 domain containing 1 (SPRED1), Protocadherin 9 (PCDH9) and Vesicle-associated membrane protein-associated protein A (VAPA
equi was accomplished by amplification of the choE gene and detection of the virulence plasmid by amplification of the vapA
gene by using multiplex PCR (5).
equi by polymerase chain reaction (PCR), a widely used molecular method, is possible through detection of the vapA
gene present in an 85 kb plasmid associated with virulence.
 Salatic I, Kiralj K, Mitic G, Veselinovic I, Vapa
(1991a) observaram que o soro de potros infectados continham invariavelmente altos niveis de anticorpos contra um antigeno de aproximadamente 15-17kDa, correspondente a uma lipoproteina expressa na superficie celular, que foi posteriormente denominada VapA
(TAN et al., 1995).