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The hepatic synthesis of VDBP is stimulated by estrogen as seen in various studies that showed increase in serum concentration of VDBP in pregnant females and in women taking exogenous estrogen.9 Menopause either involutional or estrogen related is associated with increased bone turnover and risk of osteoporotic fracture owing to multiple factors including low levels of total circulating vitamin D and VDBP.10 The current study was designed to compare the serum levels of vitamin D, VDBP, calcium, phosphate along with biophysical parameters in normal, postmenopausal osteopenic and osteoporotic women and also to examine the relationship between vitamin D, VD, BP and BMD in all three groups.
VDBP, which is coded by the GC gene, binds to 85-90% of 25 (OH) D in the circulation and thus regulates vitamin D bioavailability (19).
Figure 2 shows the association of VDBP clearance ratio with microvascular and macrovascular complications of diabetes.
Few reports show association between the VDBP polymorphism and T2DM.
While the within person CV ([CV.sub.W]) of some biomarkers of vitamin D status such as 25(OH)D, calcium and phosphorus are long established, other biomarkers like VDBP, FGF23, free 25(OH)D and bioavailable 25(OH)D have only recently garnered interest (10, 11) and their short-term variability has not yet been studied.
The VDBP may also play an important role in this process, whereby high affinity VDBP can prevent conversion of 25(OH)[D.sub.3] to 1,25[(OH).sub.2][D.sub.3] by DCs and thus their ability to modulate [T.sub.Reg] cell activity .
The evolutionarily close proteins of albumin superfamily are comprised of albumin (ALB), [alpha]-fetoprotein (AFP), vitamin D-binding protein (VDBP), and afamin (AFM).
Whether cutaneously produced or injected, vitamin D3 is bound to Vitamin D Binding Protein (VDBP) and circulated throughout the body.
A key protein in vitamin D metabolism is the vitamin D binding protein (VDBP), formerly known as "group-specific component" (Gc).
(2006) 'Patterns of emotional responses to affective situations.' An Unpublished paper, VDBP.
Vitamin D-binding protein (VDBP) (primary accession number P02774; http://www.uniprot.org/uniprot/P02774), also known as gc-globulin, is a 58kDa glycoprotein which serves as the main carrier protein for circulating vitamin D and its metabolites, supporting the bioavailability of active 1,25-dihydroxyvitamin D (1,25[(OH).sub.2]D) and its precursor 25-hydroxyvitamin D (25OHD) [18,19].
Objective: To investigate the relationship of vitamin D deficiency and risk of AMI in a Pakistani population, and to find out any association between vitamin D binding protein (VDBP) genotypes and risk of AMI in this population.
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- VDD Sag