Given that VDPV
was found in the city of Manila, Duque called on local governments to intensify the implementation of their zero open-defecation program as well as to strengthen their efforts to ensure good personal hygiene and sanitation.
This research implies that the studied sIPV is as effective as IPV in preventing poliovirus infection in infants aged 60-90 days, can be a reliable alternative to conventional IPV and can be a good supplement to OPV in potentially preventing or minimizing VDPV
emergence or VAPP.
GPLN laboratories implement standardized protocols to 1) isolate and identify polioviruses; 2) conduct intratypic differentiation (ITD) to identify WPV, Sabin (vaccine) poliovirus, and VDPV
; and 3) conduct genomic sequencing.
Scientists are working around the clock to try and produce a vaccination that won't cause VDPV
. Until then, the OPV is the only readily accessible vaccination in many poor countries.
All 13 VDPV
isolates showed discordant intratypic differentiation results and were further characterized by sequencing the VP1 capsid coding region (Table 4).
More complex is the post-eradication phase and, specifically, the risk of wild-type virus escape and VDPV
types 1 or 3 are polioviruses that are >1% divergent ([greater than or equal to] 10 nucleotide differences in the genetic sequence) from the corresponding Sabin OPV strain in the viral protein 1 (VP1) genomic coding region (1,4).
Although there was no chronic (>5 years) poliovirus excreter among the participants, we identified 1 patient with SCID as a long-term (>6 months) VDPV3 excreter who was excreting VDPV
for 2 years.
The continued expansion of sewage sampling (244 sites in 41 countries) (8) has increased the frequency of detection of WPV, VDPV
, and residual PV2 excretion after mOPV2 vaccination during outbreak responses.
Screening for VDPV
shedding was performed by using an ELISA, reverse transcription PCR, or real-time reverse transcription PCR.